UXAB_PHOV8
ID UXAB_PHOV8 Reviewed; 479 AA.
AC A6L4U5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Altronate oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00670};
DE EC=1.1.1.58 {ECO:0000255|HAMAP-Rule:MF_00670};
DE AltName: Full=Tagaturonate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00670};
DE AltName: Full=Tagaturonate reductase {ECO:0000255|HAMAP-Rule:MF_00670};
GN Name=uxaB {ECO:0000255|HAMAP-Rule:MF_00670}; OrderedLocusNames=BVU_3075;
OS Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Phocaeicola.
OX NCBI_TaxID=435590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC 11154;
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH;
CC Xref=Rhea:RHEA:17813, ChEBI:CHEBI:15378, ChEBI:CHEBI:17360,
CC ChEBI:CHEBI:17886, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.58;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00670};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000255|HAMAP-Rule:MF_00670}.
CC -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00670}.
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DR EMBL; CP000139; ABR40709.1; -; Genomic_DNA.
DR RefSeq; WP_005846561.1; NC_009614.1.
DR AlphaFoldDB; A6L4U5; -.
DR SMR; A6L4U5; -.
DR STRING; 435590.BVU_3075; -.
DR EnsemblBacteria; ABR40709; ABR40709; BVU_3075.
DR KEGG; bvu:BVU_3075; -.
DR eggNOG; COG0246; Bacteria.
DR HOGENOM; CLU_027324_1_0_10; -.
DR OMA; VVIVRPI; -.
DR OrthoDB; 1442117at2; -.
DR BioCyc; BVUL435590:G1G59-3199-MON; -.
DR UniPathway; UPA00246; -.
DR Proteomes; UP000002861; Chromosome.
DR GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1040.10; -; 1.
DR HAMAP; MF_00670; Altron_oxidoreduct; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR023668; Altronate_OxRdtase.
DR InterPro; IPR013118; Mannitol_DH_C.
DR InterPro; IPR013131; Mannitol_DH_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01232; Mannitol_dh; 1.
DR Pfam; PF08125; Mannitol_dh_C; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..479
FT /note="Altronate oxidoreductase"
FT /id="PRO_1000044700"
FT BINDING 18..29
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00670"
SQ SEQUENCE 479 AA; 53904 MW; 3D62C2A140C6764E CRC64;
MKALNKETAA KTQRPERIIQ FGEGNFLRAF VDWIIYNMNE KTDFNSSVVV VQPIEKGMVD
MLNAQDCLYH VNLQGLDKGQ VVNSLTKIDV ISRALNPYSQ NDEFMKLAEQ PEMRFVISNT
TEAGIAFDPA CKLDDAPASS YPGKLTQLLY HRYKTFNGDK SKGLIIFPCE LIFLNGHKLK
ETIYQYIDLW NLGEDFKQWF EEACGVYATL VDRIVPGFPR KDIAAIKEKL QYDDNLVVQA
EIFHLWVIEA PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGI
NIVREACEHE VVGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF VDHQVTSIML
NSFPKYETRD LPGLKVYLER KGELPKGLVL GLAAIITYYK GGVRADGAEI VPNDAPEIMN
LLKELWATGC TQKVAEGVLA AESIWGENLN NIPGLTAAVK ADLDSIQEKG MLETVKGIL
