ID   UXAB_YERPN              Reviewed;         483 AA.
AC   Q1CMJ9; C4GP05;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Altronate oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00670};
DE            EC=1.1.1.58 {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate reductase {ECO:0000255|HAMAP-Rule:MF_00670};
GN   Name=uxaB {ECO:0000255|HAMAP-Rule:MF_00670}; OrderedLocusNames=YPN_0449;
GN   ORFNames=YP516_0464;
OS   Yersinia pestis bv. Antiqua (strain Nepal516).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=377628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RA   Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA   Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R.,
RA   Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.;
RT   "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH;
CC         Xref=Rhea:RHEA:17813, ChEBI:CHEBI:15378, ChEBI:CHEBI:17360,
CC         ChEBI:CHEBI:17886, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.58;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00670};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00670}.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00670}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000305; ABG16781.1; -; Genomic_DNA.
DR   EMBL; ACNQ01000006; EEO78237.1; -; Genomic_DNA.
DR   RefSeq; WP_002210409.1; NZ_ACNQ01000006.1.
DR   AlphaFoldDB; Q1CMJ9; -.
DR   SMR; Q1CMJ9; -.
DR   EnsemblBacteria; ABG16781; ABG16781; YPN_0449.
DR   GeneID; 57974036; -.
DR   KEGG; ypn:YPN_0449; -.
DR   HOGENOM; CLU_027324_1_0_6; -.
DR   OMA; VVIVRPI; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000008936; Chromosome.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   HAMAP; MF_00670; Altron_oxidoreduct; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR023668; Altronate_OxRdtase.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..483
FT                   /note="Altronate oxidoreductase"
FT                   /id="PRO_1000044710"
FT   BINDING         18..29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00670"
SQ   SEQUENCE   483 AA;  54907 MW;  BDDB13837F6564B4 CRC64;
     MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV IRPIDTDFPP
     SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR QFDDYLALAR DANIRFMFSN
     TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL FERFEHFDGA ADKGWVLLPC ELIDYNGEAL
     RELVLRYASH WQLPAAFTHW LTENNTFCST LVDRIVTGYP RDEVAALQTE LGYQDSFLDT
     AEYFYLFVIQ GPQGLAQELR LDQLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG
     LDTVGQTMDD AQISRFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP FIQHQLLSIA
     LNGMTKFRTR ILPQLLTYQQ QKGQLPPRLT FALAALIAFY RGEREGQTYP LQDDAHWLER
     YSTLWNGVKH GDIALAELVN RVLSDANHWG QDLTAVPQLA NQVTEQLQTI LSRGMRAAVA
     AYS