ID   UXAC_ACTSZ              Reviewed;         467 AA.
AC   A6VKM8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Asuc_0145;
OS   Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS   130Z).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=339671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z;
RX   PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA   McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA   Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA   Burkhart K.B., Harkins V., Vieille C.;
RT   "A genomic perspective on the potential of Actinobacillus succinogenes for
RT   industrial succinate production.";
RL   BMC Genomics 11:680-680(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000746; ABR73525.1; -; Genomic_DNA.
DR   RefSeq; WP_011978801.1; NC_009655.1.
DR   AlphaFoldDB; A6VKM8; -.
DR   SMR; A6VKM8; -.
DR   STRING; 339671.Asuc_0145; -.
DR   PRIDE; A6VKM8; -.
DR   EnsemblBacteria; ABR73525; ABR73525; Asuc_0145.
DR   KEGG; asu:Asuc_0145; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001114; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000072724"
SQ   SEQUENCE   467 AA;  54150 MW;  33BCEF1EAD6CB215 CRC64;
     MKQFMDEDFL LSNDVARTLY FDYAKDQPIF DYHCHLPPKE IAENRLFKDL TEIWLAGDHY
     KWRAMRSAGF DENVITGNAS AYEKYQAWAK TVPLCIGNPI YHWTHLELRR PFGITDTLFG
     PQSADKIWQE CNELLQQPEF SARGIMRRMN VKFSGTTDDP IDSLEYHKAI AEDNAFDIEV
     APSWRPDKAV KIELDQFNDY LEQLERVSDT DINSFDALKK ALLKRLEHFD QHGCKSADHG
     MEIVRFAPIP DEKELDRILR LRRSNQALTE LQINQYSTAL LVWLGTEYCK RNWAMQMHIG
     ALRNNNTRMF KLLGADAGFD SIADRTFAEP LSRLLDTMDQ NDELPKTILY CLNPRDNEMI
     ATMIGNFQTG GVAGKIQFGS GWWFNDQKDG MERQLQQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CEMVGKWVVN GEAPNDMNLL GNMVKNICYN NAKSYFK