ID   UXAC_ALKCK              Reviewed;         472 AA.
AC   Q5WJC1;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=ABC0995;
OS   Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16;
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AP006627; BAD63534.1; -; Genomic_DNA.
DR   RefSeq; WP_011245850.1; NC_006582.1.
DR   AlphaFoldDB; Q5WJC1; -.
DR   SMR; Q5WJC1; -.
DR   STRING; 66692.ABC0995; -.
DR   PRIDE; Q5WJC1; -.
DR   EnsemblBacteria; BAD63534; BAD63534; ABC0995.
DR   KEGG; bcl:ABC0995; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172760"
SQ   SEQUENCE   472 AA;  53983 MW;  8274B351590594E7 CRC64;
     MISTGKAFIH ENFMLQNKTA ETLYHTYAKT LPIIDYHCHV PPQEIAENRQ FNNISEIWLH
     GDHYKWRAMR AVGVEETFIT GDGDDKEKFL KWAETVPYTM GNPLYHWTHL ELKRYFGIDE
     LLSSETAEAI WSATKEQLAA PERSVQGIIK ESNVKVICTT DDPSDHLEAH QQIRKEGACQ
     AAVYPAFRPD KALVASAPSF VPYLETLGAA AEVDISSLRS LLEALEKRAT FFAEEGCVLS
     DHGLRTLPFV DTTEKEAEAA FQKALNQETL TPQEEEKYQT YVLLFLARLY NKLGWTMQFH
     LGALRNNNSR MVEQVGPDSG FDSMADDRFA ESLNRFLNEL ERTNELPKTI LYTLNPIFNE
     VIATTIGNFQ GGGIPGKIQF GSGWWFNDTK DGMEKQMTDL ANNGLLSLFV GMLTDSRSFL
     SYTRHEYFRR ILCNRIGEWV ERGEWPADEK WLGKVVEDIS YYNAKRYFAF PK