ID   UXAC_ALKHC              Reviewed;         472 AA.
AC   Q9KEZ4;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=BH0705;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; BA000004; BAB04424.1; -; Genomic_DNA.
DR   PIR; A83738; A83738.
DR   RefSeq; WP_010896878.1; NC_002570.2.
DR   AlphaFoldDB; Q9KEZ4; -.
DR   SMR; Q9KEZ4; -.
DR   STRING; 272558.10173319; -.
DR   PRIDE; Q9KEZ4; -.
DR   EnsemblBacteria; BAB04424; BAB04424; BAB04424.
DR   KEGG; bha:BH0705; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172758"
SQ   SEQUENCE   472 AA;  54762 MW;  949EBC414EEFDC32 CRC64;
     MTNFLSEDFL LMNEYDRELY YTFAKNMPIC DYHCHLSPQE IWENKPFENM TKAWLGGDHY
     KWRAMRLNGV REEFITGGAP DKEKFLAWAK TVPKTIGNPL YHWTHMELKT YFHFHQPLDE
     TNGENVWDAC NRLLQQEAFT PRALIERSNV RAIGTTDDPT DSLLYHQKLQ ADDTFHVKVI
     PTFRPDGALK IEQDSFADWV AKLSDVTGES LDTLDAFLHA LKERLTFFDE HGCRSSDHDM
     TEVPFVEVNE QEAQHIFRKR LANEGLTKVE NEKYKTFLMT WLGKEYAARG WVMQWHIGVM
     RNNNSRMLHK LGPDTGFDSI GDGQIAHATA KLLDLLDKQG ALPKTILYCV NPNANYILAS
     MIGNFTESGV RGKVQFGSAW WFNDHIDGMR RQLTDLASVG LLSNFIGMLT DSRSFLSYPR
     HDYFRRILCQ LIGSWIKEGQ LPPDMERWGQ IVQDICYNNV VDYFDMKETV RL