UXAC_BACFR
ID UXAC_BACFR Reviewed; 468 AA.
AC Q64TY9;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=BF2293;
OS Bacteroides fragilis (strain YCH46).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=295405;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YCH46;
RX PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT regulating cell surface adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP006841; BAD49040.1; -; Genomic_DNA.
DR RefSeq; WP_005793937.1; NC_006347.1.
DR RefSeq; YP_099574.1; NC_006347.1.
DR AlphaFoldDB; Q64TY9; -.
DR SMR; Q64TY9; -.
DR STRING; 295405.BF2293; -.
DR EnsemblBacteria; BAD49040; BAD49040; BF2293.
DR KEGG; bfr:BF2293; -.
DR PATRIC; fig|295405.11.peg.2222; -.
DR HOGENOM; CLU_044465_1_0_10; -.
DR OMA; TDHGHPT; -.
DR UniPathway; UPA00246; -.
DR Proteomes; UP000002197; Chromosome.
DR GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR HAMAP; MF_00675; UxaC; 1.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR003766; Uronate_isomerase.
DR Pfam; PF02614; UxaC; 1.
DR SUPFAM; SSF51556; SSF51556; 1.
PE 3: Inferred from homology;
KW Isomerase.
FT CHAIN 1..468
FT /note="Uronate isomerase"
FT /id="PRO_0000172757"
SQ SEQUENCE 468 AA; 54658 MW; B4271EE3A2CBE3B5 CRC64;
MKNFMDKNFL LQTETAQELY HNHAAKMPII DYHCHLNPQM VADDYRFKSL TEIWLGGDHY
KWRAMRSNGV DECFCTGKET SDWEKFEKWA ETVPYTFRNP LYHWTHLELK TAFGIDKVLN
PKTAREIYDE CNEKLSSQEY SARGMMRRYH VETVCTTDDP IDSLEYHIRT RESGFEIKML
PTWRPDKVMA VEVPSDFRTY IEKLSEISEI TISDYNDMIL ALRKRHDYFA EQGCKLSDHG
IEEFYAEDYT EGEIKTIFNK IYGGSELTKE EVLKFKSAML IVLGEMDWEK GWTQQFHYGA
IRNNNSRMFK QLGPDTGFDS IGEFATAKAM SKFLDRLNSK GKLTKTILYN LNPCANEVIA
TMIGNFQDGS IPGKIQFGSG WWFLDQKDGM ERQLNALSLL GLLSRFVGML TDSRSFLSYP
RHEYFRRTLC NLLGCDVENG EIPLSEMERV CQMVEDISYF NAKNFFHF