ID   UXAC_BACLD              Reviewed;         473 AA.
AC   Q65F21; Q62QI7;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675};
GN   OrderedLocusNames=BLi03516, BL00708;
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=279010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15383718; DOI=10.1159/000079829;
RA   Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA   Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT   "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT   with great industrial potential.";
RL   J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AE017333; AAU42343.1; -; Genomic_DNA.
DR   EMBL; CP000002; AAU24973.1; -; Genomic_DNA.
DR   RefSeq; WP_009329570.1; NC_006322.1.
DR   AlphaFoldDB; Q65F21; -.
DR   SMR; Q65F21; -.
DR   STRING; 279010.BL00708; -.
DR   EnsemblBacteria; AAU24973; AAU24973; BL00708.
DR   KEGG; bld:BLi03516; -.
DR   KEGG; bli:BL00708; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; VSMHGHV; -.
DR   OrthoDB; 167900at2; -.
DR   BioCyc; BLIC279010:BLI_RS17320-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000606; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..473
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172759"
SQ   SEQUENCE   473 AA;  54379 MW;  F01EAF06663576AD CRC64;
     MKPFLNDDFL LTNETSKVLY HQYAKGMPII DYHCHLSPKE IYENKTFKNL TEVWLYGDHY
     KWRAMRANGI SEEFITGDAS DEEKFSAWAR TVPMTIGNPL YHWTHLELRR FFGIDDRLDE
     KSAPHIWERV NEQLAGGGFG ARDLIEKSNV ETVVTTDDPT DSLEYHVKLK DEDFNVSVLP
     GFRPDKAMEI NQEGFAAWVR KLETASGMKI ANYDDFLKAL KNRIDFFHEA GGRISDHAIN
     QMMYTETDES EVRPIFAKVM NGESASPEEE CKFKSLTLHF LGTCYAEKGW AMQLHINALR
     NNSSKMYRKL GPDTGYDAIN DQDIAKPLCS FLDSLDRKDA LPKTILYSLN PRDNVVISSL
     CGSFQDGRIP GKIQHGTAWW FNDTKDGMLE QMKSLANIGL LSRFIGMLTD SRSFLSYTRH
     EYFRRLLCDV IGTWVENGEA PDDIELLGRI VKGICYENAK HYFQFEVKDR LKA