ID   UXAC_BACTN              Reviewed;         468 AA.
AC   Q8A9J2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2003, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=BT_0823;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO75930.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015928; AAO75930.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_809736.2; NC_004663.1.
DR   RefSeq; WP_008765680.1; NC_004663.1.
DR   AlphaFoldDB; Q8A9J2; -.
DR   SMR; Q8A9J2; -.
DR   STRING; 226186.BT_0823; -.
DR   PaxDb; Q8A9J2; -.
DR   PRIDE; Q8A9J2; -.
DR   EnsemblBacteria; AAO75930; AAO75930; BT_0823.
DR   GeneID; 60926793; -.
DR   KEGG; bth:BT_0823; -.
DR   PATRIC; fig|226186.12.peg.839; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_10; -.
DR   InParanoid; Q8A9J2; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019698; P:D-galacturonate catabolic process; IBA:GO_Central.
DR   GO; GO:0042840; P:D-glucuronate catabolic process; IBA:GO_Central.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..468
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172763"
SQ   SEQUENCE   468 AA;  54317 MW;  29FB39B6AA5C5B84 CRC64;
     MKNFMDENFL LQTETAQKLY HEHAAKMPII DYHCHLIPQM VADDYKFKSL TEIWLGGDHY
     KWRAMRTNGV DERYCTGKDT TDWEKFEKWA ETVPYTFRNP LYHWTHLELK TAFGIDKILS
     PKTAREIYDE CNEKLAQPEY SARGMMRRYH VEVVCTTDDP IDSLEYHIQT RESGFEIKML
     PTWRPDKAMA VEVPADFRAY VEKLSAVSGV TISNFDDMIA ALRKRHDFFA EQGCRLSDHG
     IEEFYAEDYT DAEIKAIFNK VYGGAELTKE EILKFKSAML VIFGEMDWEK GWTQQFHYGA
     IRNNNTKMFK LLGPDTGFDS IGEFTTAKAM SKFLDRLNVN GKLTKTILYN LNPCANEVIA
     TMLGNFQDGS IAGKIQFGSG WWFLDQKDGM EKQMNALSVL GLLSRFVGML TDSRSFLSYP
     RHEYFRRTLC NLVGRDVENG EIPVSEMDRV NQMIEDISYN NAKNFFKF