ID   UXAC_BACVZ              Reviewed;         465 AA.
AC   A7Z3M5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=RBAM_012380;
OS   Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
OS   (Bacillus amyloliquefaciens subsp. plantarum).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus amyloliquefaciens group.
OX   NCBI_TaxID=326423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42;
RX   PubMed=17704766; DOI=10.1038/nbt1325;
RA   Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K.,
RA   Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H.,
RA   Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H.,
RA   Strittmatter A., Gottschalk G., Borriss R.;
RT   "Comparative analysis of the complete genome sequence of the plant growth-
RT   promoting bacterium Bacillus amyloliquefaciens FZB42.";
RL   Nat. Biotechnol. 25:1007-1014(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000560; ABS73601.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7Z3M5; -.
DR   SMR; A7Z3M5; -.
DR   STRING; 326423.RBAM_012380; -.
DR   EnsemblBacteria; ABS73601; ABS73601; RBAM_012380.
DR   KEGG; bay:RBAM_012380; -.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; VSMHGHV; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001120; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..465
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044760"
SQ   SEQUENCE   465 AA;  53207 MW;  678EB6B829EC1D84 CRC64;
     MKAFMGDDFL LNSKTAVKLY REYAENMPII DYHCHLSPKE IYENKTFATI TEAWLYGDHY
     KWRIMRANGI EERCITGNAS DEEKFFAWAK TVPMAIGNPL YSWTHLELQR WFGIYDVLNE
     KTAAAIWKKT NELLQGDGFG ARDLILKSNV KVICTTDDPA DALTYHELLK ESDFPVQVLP
     GFRPDKGLDI SSPGFADWVR SLESASGMAV SSYQSYLDAL ESRVRFFHNA GGRVSDHALD
     QMVYAETTEE EAARIFAAGL SGEHVSFEDE KKFKTRTLQY LCGLYAELDW AMQFHINALR
     NTNTNKFSSL GPDTGYDSIN DERIAKPLAR LLDSAEKKRQ LPKTILYSLN PNDNYIIASM
     INSFQDGKTP GKIQFGTAWW FNDTKDGMLQ QMRALSNMGL FSRFIGMLTD SRSFLSYPRH
     EYFRRLVCTL IGGWAEQGEA PYDMELLGKI VEGICYRNAE EYFRF