ID   UXAC_BRAHW              Reviewed;         468 AA.
AC   C0QWA9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=BHWA1_02239;
OS   Brachyspira hyodysenteriae (strain ATCC 49526 / WA1).
OC   Bacteria; Spirochaetes; Brachyspirales; Brachyspiraceae; Brachyspira.
OX   NCBI_TaxID=565034;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49526 / WA1;
RX   PubMed=19262690; DOI=10.1371/journal.pone.0004641;
RA   Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P.,
RA   Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A.,
RA   Barrero R., Phillips N.D., Hampson D.J.;
RT   "Genome sequence of the pathogenic intestinal spirochete Brachyspira
RT   hyodysenteriae reveals adaptations to its lifestyle in the porcine large
RT   intestine.";
RL   PLoS ONE 4:E4641-E4641(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001357; ACN84695.1; -; Genomic_DNA.
DR   RefSeq; WP_012671727.1; NC_012225.1.
DR   AlphaFoldDB; C0QWA9; -.
DR   SMR; C0QWA9; -.
DR   STRING; 565034.BHWA1_02239; -.
DR   PRIDE; C0QWA9; -.
DR   EnsemblBacteria; ACN84695; ACN84695; BHWA1_02239.
DR   GeneID; 63963393; -.
DR   KEGG; bhy:BHWA1_02239; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_12; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001803; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..468
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000147686"
SQ   SEQUENCE   468 AA;  54435 MW;  5537B2A170D74A83 CRC64;
     MKTFMDKDFL LYNETAKTLF YNYACKCPIF DYHCHLNPKE IAENKKFKNI TEIWLYGDHY
     KWRMMRANGI DEKFITGDAS DYDKFIAWVK TVPNLIGNPL YHWSHLELQR YFDIHEVINE
     DNADTIWEKA NQKLQNMTVK DILKKFKVHT IGTTDDPTDN LEYHKLINEG KAQIGKIYTK
     VVPSFRPDKA INIEMPDFSD YIKKLENASK INIKDINSLT EALYNRIDYF KSLGCVSSDC
     SLSIVPFNLD DEKNIDAIFK KAMNKESLNF EDIEKYKTYI LIKLIKKYKE SNLVMQIHIS
     AMRNNNEVMF KKLGADTGYD SVGDSNIIEK LSFLLKTANN DGGLPKIIFY SLNHKDYYPL
     STLMGCFQEG SIKGKMQLGS AWWFCDNRDG MEEQIKILAN TGSLALFVGM LTDSRSFLSY
     SRHEYFRRIL CNIIGEWADK GEVPNDIKYL GSIIENICFN NSNIYFNN