ID   UXAC_BRUC2              Reviewed;         466 AA.
AC   A9MC99;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=BCAN_B0827;
OS   Brucella canis (strain ATCC 23365 / NCTC 10854).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=483179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23365 / NCTC 10854;
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000873; ABX63986.1; -; Genomic_DNA.
DR   RefSeq; WP_004687147.1; NC_010104.1.
DR   AlphaFoldDB; A9MC99; -.
DR   SMR; A9MC99; -.
DR   EnsemblBacteria; ABX63986; ABX63986; BCAN_B0827.
DR   GeneID; 45053828; -.
DR   GeneID; 55592462; -.
DR   KEGG; bcs:BCAN_B0827; -.
DR   HOGENOM; CLU_044465_0_0_5; -.
DR   OMA; TDHGHPT; -.
DR   PhylomeDB; A9MC99; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001385; Chromosome II.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000082958"
SQ   SEQUENCE   466 AA;  52750 MW;  7334C3D0A1927802 CRC64;
     MALNPDRLFS AEPGTREIAR RLFASVEKLP IISPHGHTEP IWYARNEAFP DPASLFVKPD
     HYITRMLYSQ GHSLESLGIA SRDGRPSETD ARKIWRLFAT NWYLFRATPS RLWFEHAMET
     VFGITERLSQ ENADRIFDAI ADQLTQPHMR PRALYDRFNI EAISTTDAAT DPLIYHDEVI
     ASGWHGRIIP AYRPDAAVDA GRPDFASEVE KLVGVAGTPL TWQGYLDAHR NRREYFKRRG
     ATSSDHGHPT AQTADLSAGD ASRLFDRVIK GNASTSDAEM FRAQMLTEMA RMSIDDGLVM
     QIHPGSFRNH NPTVFERFGL DKGADIPRQT GFVDQLKPLL DAFGNDPRLT VILFTLDETA
     YSRELAPLAG HYPALKLGPA WWFFDSPEGI LRYRKLTTET AGFYNTVGFN DDTRAYLSIP
     ARHDMARRVD CAYLAGLVAD HRLEEDEAYE VAHDLAYRLA KQTYKL