ID   UXAC_BRUME              Reviewed;         466 AA.
AC   Q8YCQ2; Q8YCQ1;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2003, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Uronate isomerase;
DE            EC=5.3.1.12;
DE   AltName: Full=Glucuronate isomerase;
DE   AltName: Full=Uronic isomerase;
GN   Name=uxaC; OrderedLocusNames=BMEII0476/BMEII0477;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12;
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL53719.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE008918; AAL53718.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE008918; AAL53719.1; ALT_FRAME; Genomic_DNA.
DR   PIR; AC3569; AC3569.
DR   PIR; AD3569; AD3569.
DR   AlphaFoldDB; Q8YCQ2; -.
DR   SMR; Q8YCQ2; -.
DR   STRING; 224914.BMEII0476; -.
DR   EnsemblBacteria; AAL53718; AAL53718; BMEII0476.
DR   EnsemblBacteria; AAL53719; AAL53719; BMEII0477.
DR   KEGG; bme:BMEII0476; -.
DR   KEGG; bme:BMEII0477; -.
DR   eggNOG; COG1904; Bacteria.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172764"
SQ   SEQUENCE   466 AA;  52700 MW;  6995D2D0A1927813 CRC64;
     MALNPDRLFS AEPGTREIAR RLFASVEKLP IISPHGHTEP IWYARNEAFP DPASLFVKPD
     HYITRMLYSQ GHSLESLGIA SRDGRPSETD ARKIWRLFAT NWYLFRATPS RLWFEHAMET
     VFGITERLSQ ENADRIFDAI ADQLTQPHMR PRALYDRFNI EAISTTDAAT DPLIYHDEVI
     ASGWHGRIIP AYRPDAAVDA GRPDFASEVE KLVGVAGTPL TWQGYLDAHR NRREYFKRRG
     ATSSDHGHPT AQTADLSAGD ASRLFDRVIK GNASTSDAEM FRAQMLTEMA RMSIDDGLVM
     QIHPGSFRNH NPTVFERFGL DKGADIPRQT GFVDQLKPLL DAFGNDPRLT VILFTLDETA
     LSRELAPLAG HYPALKLGPA WWFFDSPEGI LRYRKLTTET AGFYNTVGFN DDTRAYLSIP
     ARHDMARRVD CAYLAGLVAD HRLEEDEAYE VAHDLAYRLA KQTYKL