ID   UXAC_BRUSU              Reviewed;         466 AA.
AC   Q8FVM4; G0KDH6;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675};
GN   OrderedLocusNames=BRA0812, BS1330_II0805;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AE014292; AAN33988.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM20264.1; -; Genomic_DNA.
DR   RefSeq; WP_004687147.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FVM4; -.
DR   SMR; Q8FVM4; -.
DR   PRIDE; Q8FVM4; -.
DR   EnsemblBacteria; AEM20264; AEM20264; BS1330_II0805.
DR   GeneID; 45053828; -.
DR   GeneID; 55592462; -.
DR   KEGG; bms:BRA0812; -.
DR   KEGG; bsi:BS1330_II0805; -.
DR   PATRIC; fig|204722.22.peg.2188; -.
DR   HOGENOM; CLU_044465_0_0_5; -.
DR   OMA; TDHGHPT; -.
DR   PhylomeDB; Q8FVM4; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172765"
SQ   SEQUENCE   466 AA;  52750 MW;  7334C3D0A1927802 CRC64;
     MALNPDRLFS AEPGTREIAR RLFASVEKLP IISPHGHTEP IWYARNEAFP DPASLFVKPD
     HYITRMLYSQ GHSLESLGIA SRDGRPSETD ARKIWRLFAT NWYLFRATPS RLWFEHAMET
     VFGITERLSQ ENADRIFDAI ADQLTQPHMR PRALYDRFNI EAISTTDAAT DPLIYHDEVI
     ASGWHGRIIP AYRPDAAVDA GRPDFASEVE KLVGVAGTPL TWQGYLDAHR NRREYFKRRG
     ATSSDHGHPT AQTADLSAGD ASRLFDRVIK GNASTSDAEM FRAQMLTEMA RMSIDDGLVM
     QIHPGSFRNH NPTVFERFGL DKGADIPRQT GFVDQLKPLL DAFGNDPRLT VILFTLDETA
     YSRELAPLAG HYPALKLGPA WWFFDSPEGI LRYRKLTTET AGFYNTVGFN DDTRAYLSIP
     ARHDMARRVD CAYLAGLVAD HRLEEDEAYE VAHDLAYRLA KQTYKL