ID   UXAC_CALBD              Reviewed;         464 AA.
AC   B9MS46;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Athe_1402;
OS   Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)
OS   (Anaerocellum thermophilum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX   NCBI_TaxID=521460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1888 / DSM 6725 / Z-1320;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Kataeva I., Adams M.W.W.;
RT   "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001393; ACM60500.1; -; Genomic_DNA.
DR   RefSeq; WP_015907868.1; NC_012034.1.
DR   AlphaFoldDB; B9MS46; -.
DR   SMR; B9MS46; -.
DR   STRING; 521460.Athe_1402; -.
DR   EnsemblBacteria; ACM60500; ACM60500; Athe_1402.
DR   GeneID; 31772748; -.
DR   KEGG; ate:Athe_1402; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000007723; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..464
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000147685"
SQ   SEQUENCE   464 AA;  53870 MW;  015EA716997987F5 CRC64;
     MKRFMDEDFL LNNKTAKVLY EKYAKDMPIV DFHCHLNPKE IYENKTFKNI TEVWLGGDHY
     KWRLMRTNGI EEKYITGDAD DYEKFLAWAK TIPMAIGNPI YHWTHLELKR YFGIDDVLNE
     RSAPIIWEKT NKVLKELGAR DIILKSNVEI ICTTDDPIDT LEYHLKLKED KDFNVKVYPT
     FRPDKGVNIE RETFIPWVKK LAEVYGKKIE SYDEFLDALK SRAEFFHSVG CRASDHAIDD
     MVFADASFDE VANIFKKALA GEKLTEIEFA KYKTYTLRFL GKVYSSLGWA MQLHINALRN
     NNTRMFNILG PDTGYDSIND GHIAFALVKF LDSLEKENSL PKTILYSLNP KDNYVLATIM
     GSFQGGGIPG KMQLGAAWWF NDSKDGNIQQ MKDLANLGLL SRFVGMVTDS RSFLSYARHE
     YFRRLLCNLI GEWVENGEYP YDLETLGRIV QDICYYNAKE YFGF