ID   UXAC_CALS4              Reviewed;         466 AA.
AC   Q8R8Q6;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=TTE1939;
OS   Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS   11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA   Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA   Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AE008691; AAM25118.1; -; Genomic_DNA.
DR   RefSeq; WP_011026082.1; NC_003869.1.
DR   AlphaFoldDB; Q8R8Q6; -.
DR   SMR; Q8R8Q6; -.
DR   STRING; 273068.TTE1939; -.
DR   EnsemblBacteria; AAM25118; AAM25118; TTE1939.
DR   KEGG; tte:TTE1939; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000555; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172790"
SQ   SEQUENCE   466 AA;  54325 MW;  7DA89D68B258EFB5 CRC64;
     MRKFMDEDFL LTNETAVKLY HQYAKDMSIY DFHCHLSPKE IYEDRRFKNI TEVWLYGDHY
     KWRLMRANGI DEKYITGDAD DYEKFVAYAK TIPMAIGNPV YHWTHLELQR YFGIYDLLNE
     KTAKSIWERA NEVISQEDFS ARNILKKSNV KVVITTDDPV DSLEYHIKLK EEKDFDIKVL
     PAFRPDKGLN IEKDDFLSWI KKLESASGIK ITTYDDFLQA LEKRIEFFHS VGCRISDHAL
     DYVFYQKTSK QEAEKVFKKV LTEQHLTKEE IDSFKTYTMI FLGKKYAELN WVMQLHIGAM
     RNNNTKMYRI LGPDTGYDSI GDFPIAYSLS RLLDSLEIEG ALPKTILYTL NPAANYVIAT
     MIGNFQDGKI AGKMQFGAAW WFNDNKDGIK EQLKTLANVG LLGRFVGMVT DSRSFLSYAR
     HEYFRRILCD LIGEWVENGE VPNDIELLGK IVQDISFNNA KEYMGV