UXAC_CALS8
ID UXAC_CALS8 Reviewed; 464 AA.
AC A4XKU9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Csac_1949;
OS Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T
OS 6331).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX NCBI_TaxID=351627;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A.,
RA VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J.,
RA Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M.,
RA Kengen S.M.W., Richardson P.;
RT "Genome sequence of the thermophilic hydrogen-producing bacterium
RT Caldicellulosiruptor saccharolyticus DSM 8903.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR EMBL; CP000679; ABP67534.1; -; Genomic_DNA.
DR RefSeq; WP_011917470.1; NC_009437.1.
DR AlphaFoldDB; A4XKU9; -.
DR SMR; A4XKU9; -.
DR STRING; 351627.Csac_1949; -.
DR EnsemblBacteria; ABP67534; ABP67534; Csac_1949.
DR KEGG; csc:Csac_1949; -.
DR eggNOG; COG1904; Bacteria.
DR HOGENOM; CLU_044465_1_0_9; -.
DR OMA; TDHGHPT; -.
DR OrthoDB; 167900at2; -.
DR UniPathway; UPA00246; -.
DR Proteomes; UP000000256; Chromosome.
DR GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR HAMAP; MF_00675; UxaC; 1.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR003766; Uronate_isomerase.
DR Pfam; PF02614; UxaC; 1.
DR SUPFAM; SSF51556; SSF51556; 1.
PE 3: Inferred from homology;
KW Isomerase.
FT CHAIN 1..464
FT /note="Uronate isomerase"
FT /id="PRO_1000044763"
SQ SEQUENCE 464 AA; 53757 MW; D058551E517678CB CRC64;
MKRFMDEDFL LNNQTAKVLY EKYAKDMPII DFHCHLNPKE IYENKKFRNI TEVWLGGDHY
KWRLMRANGI EEKYITGSAD DYEKFLAWAK TIPMAIGNPI YHWTHLELKR YFGIDEILNE
KSAPIIWEKA NKVLEELGAR DIILKSNVEV ICTTDDPVDT LEYHLKLKDD KNFNVKVYPT
FRPDKGVNIE RETFIPWVEK LGEVYGKKIE SYDEFLDALK SRAEFFHSVG CRASDHAIDN
MVFAEASFDE VANIFKKALA GEKLTEIEVA KYKTYTLRFL GKVYSSLGWA MQLHINALRN
NNTRMFNILG PDTGYDSIND GHIALALVKF LDSLEKENSL PKTILYSLNP KDNYVLATIM
GSFQDGSIPG KMQLGAAWWF NDSKDGNLQQ MKDLANLGLL SRFVGMVTDS RSFLSYARHE
YFRRLLCKLI GEWVENGEYP YDLEALSRIV QGVCYYNAKE YFGF
