ID   UXAC_CAUVN              Reviewed;         487 AA.
AC   B8H5V4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=CCNA_01557;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001340; ACL95022.1; -; Genomic_DNA.
DR   RefSeq; WP_010919364.1; NC_011916.1.
DR   RefSeq; YP_002516930.1; NC_011916.1.
DR   AlphaFoldDB; B8H5V4; -.
DR   SMR; B8H5V4; -.
DR   PRIDE; B8H5V4; -.
DR   EnsemblBacteria; ACL95022; ACL95022; CCNA_01557.
DR   GeneID; 7333232; -.
DR   KEGG; ccs:CCNA_01557; -.
DR   PATRIC; fig|565050.3.peg.1536; -.
DR   HOGENOM; CLU_044465_0_0_5; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   PhylomeDB; B8H5V4; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..487
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000147687"
SQ   SEQUENCE   487 AA;  55052 MW;  0FA4C80E085ED4F2 CRC64;
     MARPLSFHED RLFPSDPATR SYARGLYALV KDLPIISPHG HTDPSWFATN APFQDATDLL
     LAPDHYLFRM LYSQGVSLDA LKVRSKAGVP DTDPREAWRV FASHFYLFRG TPSWVWLNHV
     FSQVFGFTEF LEASNADDYF DRITAALATD AFRPRALFDR FNIETLATTE GPHESLQHHA
     AIRESGWGGH VITAYRPDAV IDFEDERSPR AFERFAETSG QDVYSWKSYL EAHRLRRQAF
     IDAGATSSDH GHPTAATADL SDVEAEALFN SLVKGDVTPE KAELFRAQML TEMAKMSLDD
     GLVMQIHPGS HRNHNVGLLN SHGRDKGADI PMRTEYVDAL KPLLTRLGND PRLSIILFTL
     DETTYSRELA PLAGHYPVLK LGPSWWFHDS PEGMMRFREQ VTETAGFYNT VGFNDDTRAF
     LSIPARHDVA RRVDSAFLAR MVAEHRMDLV EAEELIVDLT YNLPKKAYKL DQRPDWARPA
     TLRAAAE