ID   UXAC_CELJU              Reviewed;         471 AA.
AC   B3PBK5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=CJA_2772;
OS   Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp.
OS   cellulosa).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Cellvibrio.
OX   NCBI_TaxID=498211;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ueda107;
RX   PubMed=18556790; DOI=10.1128/jb.01701-07;
RA   DeBoy R.T., Mongodin E.F., Fouts D.E., Tailford L.E., Khouri H.,
RA   Emerson J.B., Mohamoud Y., Watkins K., Henrissat B., Gilbert H.J.,
RA   Nelson K.E.;
RT   "Insights into plant cell wall degradation from the genome sequence of the
RT   soil bacterium Cellvibrio japonicus.";
RL   J. Bacteriol. 190:5455-5463(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000934; ACE83805.1; -; Genomic_DNA.
DR   RefSeq; WP_012488366.1; NC_010995.1.
DR   AlphaFoldDB; B3PBK5; -.
DR   SMR; B3PBK5; -.
DR   STRING; 498211.CJA_2772; -.
DR   EnsemblBacteria; ACE83805; ACE83805; CJA_2772.
DR   KEGG; cja:CJA_2772; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001036; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..471
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131587"
SQ   SEQUENCE   471 AA;  54565 MW;  7933A365B9AAEC7F CRC64;
     MSFIHDDFLL DTQQAKVLYH EYAKNMPIID YHCHLPPEQV GQNKQFRNLY EVWLAGDHYK
     WRAMRSNGVD ERYCTGNASD WEKFEKWCET VPYTLRNPLY HWTHLELRKP FGITDRLLDS
     RSAKRTWDEC NELLATPEFS ARGLMTQANV KLVCTTDDPI HDLAHHKTVA ADKSFKTAML
     PTWRPDRAMM VEDAESYNKY LDRLAITADI NINTFDDLIK ALQIRHDYFH ENGCRLSDHG
     LETVYAADYT DSEIKAIFLK IRAHKQLDAV EIEKFQSAMM VEFALQDHAK GWVQQFHIGA
     IRNNNPRLFR TLGPDTGFDS IGDHNYAKPL AKFLGRLDDQ NKLAKTILYN LNPRDNEMIG
     TMIGNFQDGS AAGKIQFGSG WWFLDQMEGM TRQIEALSQL GLLSRFVGML TDSRSFLSYS
     RHEYFRRILC GIFGRDMVKG LVPDDTHMVG KMIQDISFNN AKNYFPFVVP E