ID   UXAC_CLOPE              Reviewed;         466 AA.
AC   Q8XP14;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=CPE0152;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; BA000016; BAB79858.1; -; Genomic_DNA.
DR   RefSeq; WP_011009640.1; NC_003366.1.
DR   AlphaFoldDB; Q8XP14; -.
DR   SMR; Q8XP14; -.
DR   STRING; 195102.gene:10489396; -.
DR   PRIDE; Q8XP14; -.
DR   EnsemblBacteria; BAB79858; BAB79858; BAB79858.
DR   KEGG; cpe:CPE0152; -.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172768"
SQ   SEQUENCE   466 AA;  54441 MW;  25ECEA6E5C201897 CRC64;
     MKKFMDKDFL LENEVAKVLY HNYASKVPVF DYHCHLVPME IATDHKFKNL TEMWLYHDHY
     KWRAMRSFGI DEEYITGNAS DYDKFYQFAK MMPYLIGNPI YHWSHLELKR FFGVEETLSE
     KTASTIWEKC NKVIENNNLT AKKLIEMANV VYIGTTDDPI DDLRYHKQLK EDINFKCSVN
     PSFRPEKAMK IQNEGFKEYI GKLAEVSNVE IKSFDDLKKA LEIRLDYFYE NGCMITDHSL
     ERVVFYKFSC EEINEIFIKA LNGENINNEE ASKYSVALLI SLGKMYAERN MVMQLHIGAL
     RNNNTRMFNR IGADAGFDSI DDGEIAYSLS RILDELDKED KLPKTILYCL NPKDNEVLGT
     MIGNFQGGNI AGKIQFGSGW WFNDQKDGME RQMMALSQLG LISQFVGMVT DSRSFLSYTR
     HEYFRRILCN YLGNLVESGQ YPYEEEILGE IVQNICYKNS AKYFKR