ID   UXAC_COREF              Reviewed;         469 AA.
AC   Q8FMX2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2003, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=CE2377;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC19187.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000035; BAC19187.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_006768383.1; NZ_GG700683.1.
DR   AlphaFoldDB; Q8FMX2; -.
DR   SMR; Q8FMX2; -.
DR   STRING; 196164.23494220; -.
DR   EnsemblBacteria; BAC19187; BAC19187; BAC19187.
DR   KEGG; cef:CE2377; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_11; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..469
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172769"
SQ   SEQUENCE   469 AA;  52801 MW;  657735F75D85DA4F CRC64;
     MSTSHAAHPD RLLPADPATR DIARRLLTYV EDLPIISPHG HLEASMFVKD EPFADPTTLL
     ISPDHYLTRV LHSAGVDLAD LRVGGTEGKT PREAWRIFAS NWDLYTGTAT GYWVEQEFEH
     VFGINPDRLS AENADDIYDE LSEILARPDF RPRALAEQFN LEILATTDDP LDDLADHKAL
     AQDPTFSPRV LPTFRPDAYT KMYNPGWAEK TTRLIDVAGD GKAGWEGYLQ AMRNRRQYFI
     DHGATSADHG THDTDTTPLS HEDAQRILDK GLAGTATLAE MRAFEANTTY RFAEMCQDDG
     LVMTLHPGVY RNHSASAQKK FGNDIGADIP FQLEYTRGLR PLLSDFGENK DFHFVMFTID
     ETVFSREVAP LAGYYPAAYV GAPWWFIDEI DAMNRFRSLT TGTTGFSRYS GFIDDTRAYC
     SIPARHNTSR RVEANYLARL VAEHRISETR ASEIIVDLID ASPRRVFKL