ID   UXAC_CORGL              Reviewed;         518 AA.
AC   Q8NMT1;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Uronate isomerase;
DE            EC=5.3.1.12;
DE   AltName: Full=Glucuronate isomerase;
DE   AltName: Full=Uronic isomerase;
GN   Name=uxaC; OrderedLocusNames=Cgl2484, cg2731;
OS   Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS   JCM 1318 / LMG 3730 / NCIMB 10025).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA   Ikeda M., Nakagawa S.;
RT   "The Corynebacterium glutamicum genome: features and impacts on
RT   biotechnological processes.";
RL   Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA   Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA   Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA   Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA   Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT   impact on the production of L-aspartate-derived amino acids and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12;
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000305}.
CC   -!- CAUTION: This sequence seems to be incorrect, it diverge from other
CC       UxaC orthologs in position 354. {ECO:0000305}.
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DR   EMBL; BA000036; BAB99877.1; -; Genomic_DNA.
DR   EMBL; BX927155; CAF21146.1; -; Genomic_DNA.
DR   RefSeq; NP_601685.2; NC_003450.3.
DR   RefSeq; WP_011015159.1; NC_006958.1.
DR   AlphaFoldDB; Q8NMT1; -.
DR   SMR; Q8NMT1; -.
DR   STRING; 196627.cg2731; -.
DR   KEGG; cgb:cg2731; -.
DR   KEGG; cgl:Cgl2484; -.
DR   PATRIC; fig|196627.13.peg.2417; -.
DR   eggNOG; COG1102; Bacteria.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_518480_0_0_11; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000582; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..518
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172770"
SQ   SEQUENCE   518 AA;  57454 MW;  B4579365024FACB9 CRC64;
     MTTSHASHPD RLLPADPGTR DIARRLLAHV EDLPIISPHG HLEASMFVKD EAFPDPTSLL
     ISPDHYLTRM MHSAGVDLAD LRVGGHEGKS AREAWRIFMS HWDLYAGTAT GYWVEQEFEH
     VFGINAERLN VGTPEHADAI FDELTDILAK PDFRPRALAE QFNLEVLATT DDPLDDLADH
     KALADDPTFS PRVLPTFRPD AYTKMYNAGW AEKTTKLIDT AGDGKAGWEG YLQAMRNRRQ
     YFINHGATSA DHGLHDTDTT PLSHKDAQKI LDKGLAGTAT LAEMHAFEAN TTYRFAEMSQ
     EDGLVMTIHP GVYRNHSASA QKKFGADIGA DIPFQMEFTN GLRPLLSDFG ENKDLISDSS
     FNRWLRTVSL GSTQDADMAA ASNLAANSKM ARQNTRDILD AVSDGGVMLG RNGALVLGPV
     VGTLHIKFIA PLNKRVERVM YKTGLSEAAA AEQCALEDRL REEMAHALYQ WNPGRDENYD
     LVINTGSMTY EQIVDLVVET YARKYPLHVR IIPNGKDQ