ID   UXAC_CUTAK              Reviewed;         470 AA.
AC   Q6A5D0;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=PPA2329;
OS   Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium
OS   acnes).
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=267747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16379 / KPA171202;
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal of
RT   human skin.";
RL   Science 305:671-673(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AE017283; AAT84033.1; -; Genomic_DNA.
DR   RefSeq; WP_002530879.1; NZ_CP025935.1.
DR   AlphaFoldDB; Q6A5D0; -.
DR   SMR; Q6A5D0; -.
DR   STRING; 267747.PPA2329; -.
DR   EnsemblBacteria; AAT84033; AAT84033; PPA2329.
DR   KEGG; pac:PPA2329; -.
DR   PATRIC; fig|267747.3.peg.2400; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_11; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..470
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172780"
SQ   SEQUENCE   470 AA;  52493 MW;  5115A1E18CA59D80 CRC64;
     MSTPTLTLSE DRLLPRESSA LAAAREIYRS TKGLPIISPH GHVPVSWIAD DMAFSDPTSL
     LITPDHYVNR LLHANGVDLE DLGVGRKTMS EEDNRRAFRI LCEHWRDFAG TAMRYWLVDQ
     LIGIFGITER PSPENADRIY DTIAERIAQP DFLPRALMDS FDIAFIATTD DPCDDLDGHA
     RLAADETFTR RVAPTFRPDK YLEPAAGGWT GLLARLSEVS GCDATTLDGF TEAMEDRRAY
     FRQHGAVSSD HSHRDLGTII LDHDRAASIF DASVAGRATV EEMALLRRHL FTDQARMASE
     DGLTMTVHPA VHRNHDTAAF HRFGADIGSD VPVTLEVVDS LHPLLDKFGN TDLKLVVFTI
     DETLYSREIA PLSGWYRSLY IGVPWWFIDA PESVMRFKHA VTEMAGFSRV SGMIDDTRAF
     CSIPARHDMS RRLDAAHLAE LVVLGRLDLD EAVEIAHRLV VEQPTQVFGL