ID   UXAC_ECOLI              Reviewed;         470 AA.
AC   P0A8G3; P42605; P42606; P42607; P76662; P76663; P76664; Q2M9B4;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Uronate isomerase;
DE            EC=5.3.1.12;
DE   AltName: Full=Glucuronate isomerase;
DE   AltName: Full=Uronic isomerase;
GN   Name=uxaC; Synonyms=ygjX, ygjY, ygjZ; OrderedLocusNames=b3092, JW3063;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Mizobuchi K.;
RL   Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   OPERON STRUCTURE, AND INDUCTION.
RC   STRAIN=K12 / BW25113;
RX   PubMed=19429622; DOI=10.1128/jb.00108-09;
RA   Shimada T., Yamamoto K., Ishihama A.;
RT   "Involvement of the leucine response transcription factor LeuO in
RT   regulation of the genes for sulfa drug efflux.";
RL   J. Bacteriol. 191:4562-4571(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12;
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- INDUCTION: Repressed by LeuO and H-NS. Part of the uxaCA operon.
CC       {ECO:0000269|PubMed:19429622}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000305}.
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DR   EMBL; D13328; BAA02587.1; -; Genomic_DNA.
DR   EMBL; U18997; AAA57896.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U18997; AAA57895.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U18997; AAA57894.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U00096; AAC76127.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77142.1; -; Genomic_DNA.
DR   PIR; A65098; A65098.
DR   RefSeq; NP_417563.1; NC_000913.3.
DR   RefSeq; WP_000187442.1; NZ_SSZK01000007.1.
DR   AlphaFoldDB; P0A8G3; -.
DR   SMR; P0A8G3; -.
DR   BioGRID; 4262408; 28.
DR   IntAct; P0A8G3; 9.
DR   STRING; 511145.b3092; -.
DR   jPOST; P0A8G3; -.
DR   PaxDb; P0A8G3; -.
DR   PRIDE; P0A8G3; -.
DR   EnsemblBacteria; AAC76127; AAC76127; b3092.
DR   EnsemblBacteria; BAE77142; BAE77142; BAE77142.
DR   GeneID; 67414961; -.
DR   GeneID; 947599; -.
DR   KEGG; ecj:JW3063; -.
DR   KEGG; eco:b3092; -.
DR   PATRIC; fig|511145.12.peg.3187; -.
DR   EchoBASE; EB2593; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   InParanoid; P0A8G3; -.
DR   OMA; TDHGHPT; -.
DR   PhylomeDB; P0A8G3; -.
DR   BioCyc; EcoCyc:UXAC-MON; -.
DR   BioCyc; MetaCyc:UXAC-MON; -.
DR   BRENDA; 5.3.1.12; 2026.
DR   UniPathway; UPA00246; -.
DR   PRO; PR:P0A8G3; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019698; P:D-galacturonate catabolic process; IMP:EcoCyc.
DR   GO; GO:0042840; P:D-glucuronate catabolic process; IDA:EcoCyc.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   2: Evidence at transcript level;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..470
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172771"
SQ   SEQUENCE   470 AA;  53987 MW;  9E51AA7B88411281 CRC64;
     MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL YDIWLKGDHY
     KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGKLLS
     PSTADEIWNE CNELLAQDNF SARGIMQQMN VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV
     LPSWRPDKAF NIEQATFNDY MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA
     LDVVMFAEAN EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA
     LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC LNPRDNEVLG
     TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL GLLSRFVGML TDSRSFLSYT
     RHEYFRRILC QMIGRWVEAG EAPADINLLG EMVKNICFNN ARDYFAIELN