CAGS_HELPY
ID CAGS_HELPY Reviewed; 196 AA.
AC P97227;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=CAG pathogenicity island protein 13;
GN Name=cagS; Synonyms=cag13; OrderedLocusNames=HP_0534;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 4867 / CCUG 17874 / NCTC 11638;
RX PubMed=8962108; DOI=10.1073/pnas.93.25.14648;
RA Censini S., Lange C., Xiang Z., Crabtree J., Ghiara P., Borodovsky M.,
RA Rappuoli R., Covacci A.;
RT "cag, a pathogenicity island of Helicobacter pylori, encodes type I-
RT specific and disease-associated virulence factors.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:14648-14653(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9593295; DOI=10.1046/j.1365-2958.1998.00770.x;
RA Akopyants N.S., Clifton S.W., Kersulyte D., Crabtree J.E., Youree B.E.,
RA Reece C.A., Bukanov N.O., Drazek E.S., Roe B.A., Berg D.E.;
RT "Analyses of the cag pathogenicity island of Helicobacter pylori.";
RL Mol. Microbiol. 28:37-53(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
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DR EMBL; AF282852; AAF80204.1; -; Genomic_DNA.
DR EMBL; AC000108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AE000511; AAD07600.1; -; Genomic_DNA.
DR PIR; F64586; F64586.
DR RefSeq; NP_207330.1; NC_000915.1.
DR RefSeq; WP_000069596.1; NC_018939.1.
DR PDB; 2G3V; X-ray; 2.30 A; A/B/C/D=1-196.
DR PDBsum; 2G3V; -.
DR AlphaFoldDB; P97227; -.
DR SMR; P97227; -.
DR STRING; 85962.C694_02755; -.
DR TCDB; 3.A.7.12.1; the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.
DR PaxDb; P97227; -.
DR PRIDE; P97227; -.
DR EnsemblBacteria; AAD07600; AAD07600; HP_0534.
DR KEGG; hpy:HP_0534; -.
DR PATRIC; fig|85962.47.peg.576; -.
DR OMA; MSIREMD; -.
DR EvolutionaryTrace; P97227; -.
DR Proteomes; UP000000429; Chromosome.
DR Gene3D; 1.20.120.1140; -; 1.
DR InterPro; IPR032020; CagS.
DR InterPro; IPR038306; CagS_sf.
DR Pfam; PF16707; CagS; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..196
FT /note="CAG pathogenicity island protein 13"
FT /id="PRO_0000089283"
FT VARIANT 2
FT /note="S -> G (in strain: NCTC 11638)"
FT VARIANT 14
FT /note="D -> N (in strain: NCTC 11638)"
FT VARIANT 33
FT /note="S -> N (in strain: NCTC 11638)"
FT VARIANT 192
FT /note="K -> E (in strain: NCTC 11638)"
FT VARIANT 196
FT /note="V -> VQNA (in strain: NCTC 11638)"
FT HELIX 25..27
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 34..56
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 58..68
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 72..78
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 81..104
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 112..120
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 122..124
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 127..132
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 135..148
FT /evidence="ECO:0007829|PDB:2G3V"
FT TURN 149..152
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 159..167
FT /evidence="ECO:0007829|PDB:2G3V"
FT HELIX 171..179
FT /evidence="ECO:0007829|PDB:2G3V"
SQ SEQUENCE 196 AA; 23379 MW; 6048A03CF2227E08 CRC64;
MSNNMRKLFS MIADSKDKKE KLIESLQENE LLSTDEKKKI IDQIKTMHDF FKQMHTNKGA
LDKVLRNYMK DYRAVIKSIG VDKFKKVYRL LESETMELLH AIAENPNFLF SKFDRSILGI
FLPFFSKPIM FKMSIREMDS QIELYGTKLP LLKLFVMTDE EMNFYANLKT IEQYNDYVRD
LLMKFDLEKY MKEKGV
