ID   UXAC_EDWI9              Reviewed;         469 AA.
AC   C5BH54;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=NT01EI_0502;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001600; ACR67737.1; -; Genomic_DNA.
DR   RefSeq; WP_015869938.1; NC_012779.2.
DR   AlphaFoldDB; C5BH54; -.
DR   SMR; C5BH54; -.
DR   STRING; 67780.B6E78_13235; -.
DR   EnsemblBacteria; ACR67737; ACR67737; NT01EI_0502.
DR   GeneID; 7961529; -.
DR   KEGG; eic:NT01EI_0502; -.
DR   PATRIC; fig|634503.3.peg.455; -.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..469
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000212517"
SQ   SEQUENCE   469 AA;  53292 MW;  EBB29A3EF91514D3 CRC64;
     MSPFLTEDFL LDTEFARRLY HDYAEEQPIF DYHCHLPPEQ IAENYRFKNL YDIWLKGDHY
     KWRAMRTNGV AECFCTGEAS DREKFQAWAE TVPHTIGNPL YHWTHLELRR PFGITDTLLS
     ATTAEDIWTR CNRMLAEDSF TARGIMGQMN VKMVGTTDDP IDDLRHHRTI AADSSFTTKV
     LPSWRPDKAF NIEAALFSDY IVKLGAVADV DITRFADLCQ ALKVRMDHFA AHGCKVSDHA
     LDVVVYGEAD DATLDGILAR RLSGGTPGEI EVAQFKTAVL LFLGCEYRRR GWVQQYHIGA
     LRNNNTPMFE RLGPDIGFDS INDAPVAQPL SRLLDAQSRN GGLTKTILYC LNPRDNEVLG
     TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM QRQMTQLAQL GLLSRFVGML TDSRSFLSYT
     RHEYFRRILC QMIGRWVAQG EAPADIALLG SMVKNICFDN AKSYFAIEL