ID   UXAC_ENDTX              Reviewed;         468 AA.
AC   B1GZ68;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=TGRD_067;
OS   Endomicrobium trichonymphae.
OC   Bacteria; Elusimicrobia; Endomicrobia; Endomicrobiales; Endomicrobiaceae;
OC   Endomicrobium.
OX   NCBI_TaxID=1408204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18391199; DOI=10.1073/pnas.0801389105;
RA   Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T.,
RA   Sakaki Y., Toyoda A., Hattori M., Ohkuma M.;
RT   "Complete genome of the uncultured termite group 1 bacteria in a single
RT   host protist cell.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AP009510; BAG13550.1; -; Genomic_DNA.
DR   RefSeq; WP_015423079.1; NC_020419.1.
DR   RefSeq; YP_001956011.1; NC_020419.1.
DR   AlphaFoldDB; B1GZ68; -.
DR   SMR; B1GZ68; -.
DR   STRING; 471821.TGRD_067; -.
DR   EnsemblBacteria; BAG13550; BAG13550; TGRD_067.
DR   KEGG; rsd:TGRD_067; -.
DR   PATRIC; fig|471821.5.peg.108; -.
DR   HOGENOM; CLU_044465_1_0_0; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001691; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..468
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131612"
SQ   SEQUENCE   468 AA;  53876 MW;  E6E839006791685F CRC64;
     MKKFLDKDFL LSTEAAKELF HKYAEKKPIL DYHCHINPEE IAKDRQFENI SQLWLGSDHY
     KWRQMRSCGV EEKYITGNAS DSEKFQKWAE TLEKAIGNPL YHWSHLELRR YFGYEGVLNG
     ETAKEVWTIC NEKLREKSMS ARSMIKQSSV TLICTTDDPV DNLEWHKKIK EEESFDVQVL
     PTWRPDRALN IEKPGFKDYI ARFSEVSGVN ITSFKTMKEA FRKRLGFFIS SGCRTTDHAP
     EYIMYVPSSD KEVETIFDKR LSGVALSKEE ELKYKTAFML FAGGEYSKND LVMELHYGCK
     RNNNTLVFDK LGPDTGHDCI DNFAPGAQLS NFLDALDSAG QLPRTIIYSL NPNDNAVIGT
     ILGCFQDSSA LSKIQQGAAW WFNDHKPGIT EQLTSLANLG ILSNFVGMLT DSRSFLSYTR
     HEYFRRILCD LIGSWVENGE YPYDVKILSK IVSDISYDNA VRYFKFKL