ID   UXAC_FLAJ1              Reviewed;         467 AA.
AC   A5FC03;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Fjoh_4262;
OS   Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC
OS   14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=376686;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101;
RX   PubMed=19717629; DOI=10.1128/aem.01495-09;
RA   McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA   Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA   Cheng Y.Q., Stein J.L.;
RT   "Novel features of the polysaccharide-digesting gliding bacterium
RT   Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL   Appl. Environ. Microbiol. 75:6864-6875(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000685; ABQ07270.1; -; Genomic_DNA.
DR   RefSeq; WP_012026236.1; NZ_MUGZ01000031.1.
DR   AlphaFoldDB; A5FC03; -.
DR   SMR; A5FC03; -.
DR   STRING; 376686.Fjoh_4262; -.
DR   EnsemblBacteria; ABQ07270; ABQ07270; Fjoh_4262.
DR   KEGG; fjo:Fjoh_4262; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_10; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000006694; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000082962"
SQ   SEQUENCE   467 AA;  53887 MW;  C8B3A5049517CF7C CRC64;
     MSANTFIHDN FLLENKYAEE LYHNYSKNQP IIDYHNHLNP QFIAEDKIFD NITNVWINGD
     HYKWRAMRTL GIDEQFVTGN GSDKDKFLNW AKTVPYTMRN PLYHWTHLEL ARYFDIYDLL
     NEKSAEKIYT ETTEKINSQA YSTQNLLKKV NAELVCTTED PIDSLEFHKK FANNSTGIKM
     STAFRPDKAI LIANDGYNAY LDTLGDVSGV AINTFADLQA ALRNRIEFFN ANGCKLSDHG
     LDQIYFEDFT ESEISSIFKK KRENRIITPE EALKFQSAVL IFLSETYHEF GWVQQFHLGA
     LRNNNARMHR ILGPDTGWDS IGDYPQAQKL SSFLNALDSK DKLTKTIIYN LNPADNEVMA
     TMIGNFNDGS VRGKVQFGSG WWFLDQKDGM TKQLNALSNM GLISCFVGML TDSRSFLSFP
     RHEYFRRILC NLLGDEIKRG ELPNDMEWIG KLVADISYNN AKEYFKF