ID   UXAC_GEOSE              Reviewed;         473 AA.
AC   Q9ZFL8; Q09LY0;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Uronate isomerase;
DE            EC=5.3.1.12;
DE   AltName: Full=Glucuronate isomerase;
DE   AltName: Full=Uronic isomerase;
GN   Name=uxaC;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=T-6;
RX   PubMed=10368143; DOI=10.1128/jb.181.12.3695-3704.1999;
RA   Shulami S., Gat O., Sonenshein A.L., Shoham Y.;
RT   "The glucuronic acid utilization gene cluster from Bacillus
RT   stearothermophilus T-6.";
RL   J. Bacteriol. 181:3695-3704(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12;
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ868502; ABI49945.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ZFL8; -.
DR   SMR; Q9ZFL8; -.
DR   UniPathway; UPA00246; -.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..473
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172761"
SQ   SEQUENCE   473 AA;  55070 MW;  1BA3CEF5254EC38E CRC64;
     MQPFIHENFL LQNKHAEVLY HDYAKSLPII DYHCHLSAKE IAEDRRFHDM TELWLEGDHY
     KWRAMRALGV EEKYITGNAS PEEKFQAWAK TVPYCIGNPL YHWTHLELKR YFQVDALLNE
     RTWREIWNHC NDLLRQEGFS ARSFMVKSNV EWIGTTDDPL DDLADHQAIA QDPSFLVKIV
     PSFRPDAVIE INRPSFLDYV GKLGEALACR FMITISCCKP LENRVRYFHE KGCRMADHGL
     ESMPYSECGW KEANDIFQKR KNGFVLSREE EEKYKTSTLC FLARLYHSLG WVMQLHIGSI
     RNTNEKMFRR LGPNTGYDSI HDFFLAQPLN AFLNELERRD QLPKTIVYTL NPAYNYVVAS
     TVGNFQSEGV KGKVPIWRSL GGFNDSFKMA FIRHLTDLAN VGVFSTFVGM LTDSRSFVSY
     VRHEYFRRIV CNLIGSWIEK GEVPQDYDFL GKIVQDVCYF NAKQYFQVGV SGG