ID   UXAC_GEOTN              Reviewed;         467 AA.
AC   A4IP75;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=GTNG_1765;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NG80-2;
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000557; ABO67129.1; -; Genomic_DNA.
DR   RefSeq; WP_008880074.1; NC_009328.1.
DR   AlphaFoldDB; A4IP75; -.
DR   SMR; A4IP75; -.
DR   STRING; 420246.GTNG_1765; -.
DR   EnsemblBacteria; ABO67129; ABO67129; GTNG_1765.
DR   KEGG; gtn:GTNG_1765; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001578; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044767"
SQ   SEQUENCE   467 AA;  54408 MW;  D2BFC03381FE446D CRC64;
     MQPFIDDRFL LQNKHAEVLY HDYAKSLPII DYHCHLSAKE IAEDRRFHDM TELWLEGDHY
     KWRAMRALGV EEKYITGSAS PEEKFQAWAK TVPYCIGNPL YHWTHLELKR YFQVGVLLNE
     QTWKEVWDHC NELLQQEGYS ARSFMIQSNV EWIGTTDDPL DDLMDHQKIA QDSSFSIKVV
     PSFRPDAVIE INRPSFLDYV SKLGEVADLS VDDYGQLLQA LENRVRYFHE AGCRMADHGL
     ESMPYAECTL DEARVIFQKR KEGFALSREE EEKYQTFTLC FLARLYYSLG WVMQLHIGSI
     RNTNQKMFQQ LGPNTGYDSI NDFFFAQPLN AFLNRLERDG QLPKTIVYTL NPAYNYIVAS
     TIGNFPSEGV KGKVQFGAAW WFNDHQDGII RHLNDLANVG VFSTFVGMLT DSRSFLSYVR
     HEYFRRIVCN LIGSWIEKGE APQDYAFLGK IVQDICYFNA KQYFDLS