ID   UXAC_HAEI8              Reviewed;         467 AA.
AC   Q4QPJ6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=NTHI0056;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000057; AAX87051.1; -; Genomic_DNA.
DR   RefSeq; WP_011271795.1; NC_007146.2.
DR   AlphaFoldDB; Q4QPJ6; -.
DR   SMR; Q4QPJ6; -.
DR   EnsemblBacteria; AAX87051; AAX87051; NTHI0056.
DR   KEGG; hit:NTHI0056; -.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044768"
SQ   SEQUENCE   467 AA;  54153 MW;  4CC03C3DDED0B851 CRC64;
     MKQFMDENFL LSTDTAKILY HDYAKNKPIF DYHCHLNPRE VAENRQFNDL AEIWLEGDHY
     KWRALRTAGV PEELITGKAT NYQKYLAWAK TVPLCIGNPI YHWTHLELRR PFGITNMLFN
     PQNAEKIWHQ CNEMLQQPEF SARGIMQKMN VKLVGTTDDP IDSLQYHQAI KNDESFDIDV
     VPSWRPDKVF KIELPQFNDY LVQLSEIADV DIYTFADLKK ALLKRLEYFD AQGCKSADHG
     MEIVRFSAIP DESVLNSILQ KRLQNQPLLE EEVAQFSTAI LVWLASEYCK RHWVMQMHIG
     AIRNNNSRMF ALLGADSGFD SIGDRTYAYP LSRLLDAMDK ENQLPKTILY CLNPRDNEMI
     ASMIGNFQGD GIAGKIQFGS GWWFNDQKDG MERQLQQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CEMIGGWVEK GEAPNDISLL GKMIEDICFN NAKNYFK