ID   UXAC_HAEIG              Reviewed;         467 AA.
AC   A5UFL7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675};
GN   OrderedLocusNames=CGSHiGG_02740;
OS   Haemophilus influenzae (strain PittGG).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374931;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittGG;
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA   Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT   nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000672; ABQ99572.1; -; Genomic_DNA.
DR   RefSeq; WP_012054780.1; NC_009567.1.
DR   AlphaFoldDB; A5UFL7; -.
DR   SMR; A5UFL7; -.
DR   EnsemblBacteria; ABQ99572; ABQ99572; CGSHiGG_02740.
DR   KEGG; hiq:CGSHiGG_02740; -.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001990; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044769"
SQ   SEQUENCE   467 AA;  54082 MW;  79AC1FE7561D2C2D CRC64;
     MKSFMDENFL LSTDTAKILY HDYAKNKPIF DYHCHLNPRE VAENRQFNDL AEIWLEGDHY
     KWRALRTAGV PEELITGKAT NYQKYLAWAK TVPLCIGNPI YHWTHLELRR PFGITNMLFN
     PQNAEKIWHQ CNEMLQQPEF SARGIMQKMN VKLVGTTDDP IDSLQYHQAI KNDESFDIDV
     VPSWRPDKVF KIELPQFNDY LVQLSEIADV DIYTFADLKK ALLKRLEYFD AQGCKSADHG
     MEIVRFSAIP DESVLNSILQ KRLQNQPLLE EEVAQFSTAI LVWLASEYCK RHWVMQMHIG
     AIRNNNSRMF ALLGADSGFD SIGDRAYAYP LSRLLDAMDK ENQLPKTILY CLNPRDNEMI
     ASMIGNFQGD GIAGKIQFGS GWWFNDQKDG MERQLQQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CEMIGGWVEK GEAPNDISLL GKMIEDICFN NAKNYFK