ID   UXAC_HISS2              Reviewed;         467 AA.
AC   B0URH4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=HSM_0409;
OS   Histophilus somni (strain 2336) (Haemophilus somnus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=228400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2336;
RG   US DOE Joint Genome Institute;
RA   Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F.,
RA   Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M.,
RA   Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S.,
RA   Dyer D.W., Inzana T.J.;
RT   "Complete sequence of Haemophilus somnus 2336.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000947; ACA32051.1; -; Genomic_DNA.
DR   RefSeq; WP_012341255.1; NC_010519.1.
DR   AlphaFoldDB; B0URH4; -.
DR   SMR; B0URH4; -.
DR   STRING; 228400.HSM_0409; -.
DR   EnsemblBacteria; ACA32051; ACA32051; HSM_0409.
DR   GeneID; 56965717; -.
DR   KEGG; hsm:HSM_0409; -.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000082963"
SQ   SEQUENCE   467 AA;  54080 MW;  A6E43690B178BE53 CRC64;
     MMKFMTEDFL LSTSTAQKLY HDYAEEQPIF DYHCHLNPKE IAENRQFNDL AEIWLEGDHY
     KWRAMRSAGV EEHLITGSAD KYSKYLAFAN TVPKCIGNPI YHWTHLELRR PFGITDTIFS
     PETAEKIWHK GKELLQQPEF SARGIMKKMN VNLVGTTDDP IDSLEYHKAI AEDNTFDVEV
     VPSFRPDRAF KIELPLFNDY IEQLGKVADI EINTFDKLKQ ALSKRIEHFD KYGCKSADHG
     MEIVRFSPIP DEKTLDQILQ KRLNNQPIEE EEIAQFSTAL LVWLGTEYHK HHWVMQLHIG
     AIRNNNTRMF KLLGADAGFD SIGDRAFAES LSRLLDSMDQ TDQLPKTILY CLNPRDNEML
     GTMIGNFQTG GIAGKIQFGS GWWFNDQKDG MERQLQQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CEMIGGWVER GEAPNDLNLL GKMVKDICYD NAKRYFK