ID   UXAC_LACLA              Reviewed;         472 AA.
AC   Q9CF53;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=LL1628;
GN   ORFNames=L0019;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AE005176; AAK05726.1; -; Genomic_DNA.
DR   PIR; D86828; D86828.
DR   RefSeq; NP_267784.1; NC_002662.1.
DR   RefSeq; WP_010906065.1; NC_002662.1.
DR   AlphaFoldDB; Q9CF53; -.
DR   SMR; Q9CF53; -.
DR   STRING; 272623.L0019; -.
DR   PaxDb; Q9CF53; -.
DR   EnsemblBacteria; AAK05726; AAK05726; L0019.
DR   KEGG; lla:L0019; -.
DR   PATRIC; fig|272623.7.peg.1749; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172775"
SQ   SEQUENCE   472 AA;  54414 MW;  2FEF84B758115C4F CRC64;
     MKFLSEDFLL TNESAKMLFH KHAEKMPIID YHCHLEPAEI YENKKYENLT QIWLGGDHYK
     WRLLRANGIP EKLITGDGED YEKFLAFAKT LEKSFGNPIY EWTHLELKRF FHIDKLISSE
     TAKEIWDEAN QMLATDDFRP RALIKNSQVK VVCTTDDPVS TLSYHKLLAK EEKDFKVLPA
     LRPDHLISIT DGHFADYLTE LSAVSGIEIK GFKTMIKALE QRFEFFTSLG GRLSDHSLST
     YTFAETKNVD LDSILQKAKE NQTLTDLEYN QYITALILEI MKLNKKFEWT MQLHVNVNRS
     INGPALSKIG ENTGFDSMGT QANISEELTK LFSKAAELET IPKTILYSLN QNDWLELVTM
     IGCFQGEGVQ QLQLGAGWWF NDTKKGMENQ LEIFASQSLL SNFVGMLTDS RSFLSYPRHE
     YFRRVLCNFV GQLIENGRIP DNEALVGKMI EDISYNNVHD YFGFFKDEDS NQ