ID   UXAC_LACLM              Reviewed;         472 AA.
AC   A2RJK5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=llmg_0862;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM406671; CAL97457.1; -; Genomic_DNA.
DR   RefSeq; WP_011834826.1; NZ_WJVF01000014.1.
DR   AlphaFoldDB; A2RJK5; -.
DR   SMR; A2RJK5; -.
DR   STRING; 416870.llmg_0862; -.
DR   EnsemblBacteria; CAL97457; CAL97457; llmg_0862.
DR   KEGG; llm:llmg_0862; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   PhylomeDB; A2RJK5; -.
DR   BioCyc; LLAC416870:LLMG_RS04410-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044770"
SQ   SEQUENCE   472 AA;  54483 MW;  456DB196748AA48A CRC64;
     MKFLSEDFLL NNESAKLLFH EHAEKMPIID YHCHLEPAEI YENKKYENLT QIWLGGDHYK
     WRLLRANGIP EKLITGDGDD YEKFLAFAKT LEKSLGNPIY EWTHLELKRF FHIDKLISSE
     TEKEIWDEAN QMLATDDFRP RALIKNSNVK VVCTTDDPVS KLSYHKSLAK EEKDFKVLPA
     LRPDHLISIT DGHFAEYLME LSAVSGIKIK DFKTMIKALE QRFEFFTSLG GRLSDHSLST
     YTFAETKNVD LDSILQKAKE NQTLTDLEYN QYITALILEI MKLNKKFDWT MQLHVNVNRS
     INGPALRKIG ENTGFDSMGT QANISEELTK LFSKAAELEI IPKTILYSLN QNDWLELATL
     IGCFQGEGVQ QLQLGAGWWF NDTAKGMEKQ LEIFASQSLL PNFVGMLTDS RSFLSYPRHE
     YFRRVLCNFV GQLIESGRIP DDEALVGKMI EDISYNNVHD YFGFFKNEDS KQ