ID   UXAC_LACP7              Reviewed;         466 AA.
AC   A9KNI7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Cphy_2743;
OS   Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
OS   (Clostridium phytofermentans).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=357809;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700394 / DSM 18823 / ISDg;
RA   Leschine S.B., Warnick T.A., Blanchard J.L., Schnell D.J., Petit E.L.,
RA   LaTouf W.G., Copeland A., Lucas S., Lapidus A., Barry K.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T.,
RA   Bruce D., Detter J.C., Han C., Kuske C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E.A., Richardson P.;
RT   "Complete genome sequence of Clostridium phytofermentans ISDg.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000885; ABX43104.1; -; Genomic_DNA.
DR   RefSeq; WP_012200755.1; NC_010001.1.
DR   AlphaFoldDB; A9KNI7; -.
DR   SMR; A9KNI7; -.
DR   STRING; 357809.Cphy_2743; -.
DR   EnsemblBacteria; ABX43104; ABX43104; Cphy_2743.
DR   KEGG; cpy:Cphy_2743; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000370; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000082960"
SQ   SEQUENCE   466 AA;  53257 MW;  94AF40F97C02D58A CRC64;
     MKPFMDKDFL LSTETAKTLY HDYAAQVPII DYHCHINPEE IAKDRSFDTI TQVWLGGDHY
     KWRQMRSNGI DEKYITGDAS DIEKFEKWAE TLQKAIGNPL YHWSHLELQR YFDYYGTLSA
     KTSEEVFKLC NEKLSQPEMS VRGLIKESNV DTICTTDDPI DSLEWHKAIA KDSTFDVKVL
     PAWRPDKAMN LEKPDYLDYL AKLESVSGVK IASFAGLMEA LKVRLEFFNS MGCKVSDHAL
     SYVMYKPATE EEIEAIFAKR LAGGTISEME ELQFKTAFMV SVGREYNRLG WVMQLHYGTK
     RDNNVFRFNQ LGADTGFDCI NTEGSSAELA NFLNALNSSD ELPKTIIYSL NPTDNAAIGT
     VLGCFQDSTA VGKIQQGSAW WFNDNKTGMI DQMTSLANLG LLANFVGMLT DSRSFLSYTR
     HEYFRRILCE LIGNWVENGE YPNDIEFLGQ MVQDISYYNT KRYFGF