ID   UXAC_LATSS              Reviewed;         471 AA.
AC   Q38ZF1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=LCA_0129;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR936503; CAI54426.1; -; Genomic_DNA.
DR   RefSeq; WP_011373840.1; NC_007576.1.
DR   AlphaFoldDB; Q38ZF1; -.
DR   SMR; Q38ZF1; -.
DR   STRING; 314315.LCA_0129; -.
DR   EnsemblBacteria; CAI54426; CAI54426; LCA_0129.
DR   KEGG; lsa:LCA_0129; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; IWHQCNE; -.
DR   OrthoDB; 167900at2; -.
DR   BioCyc; LSAK314315:LCA_RS00600-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..471
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044772"
SQ   SEQUENCE   471 AA;  54482 MW;  C6555CFF31AA4219 CRC64;
     MQLLDDDFLL DNDMAKTLYH DYAAQMPIID FHCHLNPSEI YQNKNYTNIT RIWLNEGTYG
     DHYKWRLMRA NGVDEKYITG DGDDYLKFIE WAKTIENAYG NPLYEWTHLE LRRFFHIDER
     LTAESAPRIW EKANQLLQTD DFKPRQLIKN SNVQVVCTTD DPASDLHYHQ LLKPEEAANG
     FKTLPAMRPD QLMQIDRDGF GDYLKTLGKV AGVEIHDFAT IVTALTQRFE FFNKMGGRLS
     DHSLLTYHFE EATPAELDAI VAKGINNAAL SEHEINQYLT MLLEALMKLN TQFNWTMQFH
     INSDRDLNRP MFAKIGPDTG YDAVGTQPDI VNHISALYTK MQQTEDVPKS IFYSLNSNDW
     LELATMMGCF QGGTTQKLQL GAGWWFNDTA EGMTQQLQVF AQQSLLPHFV GMLTDSRSFL
     SYPRHEYFRR VLCSFYGRLV EQGRVPNDAA ELGRVVQNIA YNNAHDYFDF F