ID   UXAC_MANSM              Reviewed;         467 AA.
AC   Q65V59;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=MS0544;
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E;
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU37151.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016827; AAU37151.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011199723.1; NC_006300.1.
DR   AlphaFoldDB; Q65V59; -.
DR   SMR; Q65V59; -.
DR   STRING; 221988.MS0544; -.
DR   EnsemblBacteria; AAU37151; AAU37151; MS0544.
DR   KEGG; msu:MS0544; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172776"
SQ   SEQUENCE   467 AA;  54249 MW;  4386F3AD4637FF22 CRC64;
     MKQFMDEDFL LSNDVARTLY YDYAKDQPIF DYHCHLPPKE IAENRQFKDL TEIWLAGDHY
     KWRAMRSAGV DENLITGNAS NYEKYQAWAK TVPLCIGNPI YHWTHLELRR PFGITNTLFN
     PQSADKIWQE CNELLQQPEF SARGIMRQMN VKFSGTTDDP IDSLEYHKAI AEDRDFDIEV
     APSWRPDKAV KIELPQFNDY IKQLEQVSDT EINGFDSLKK ALSKRLDHFD KRGCKSADQG
     MEIVRFAPVP DEKELDRILQ LRRNEQPLTE LQISQFSTAL LVWLGAEYCK RNWVMQMHIG
     ALRNNNTRMF KLLGADSGFD SIADRTFAEQ LSRLLDAMDQ NNQLPKTILY CLNPRDNEMI
     ATMIGNFQTG GIAGKIQFGS GWWFNDQKDG MERQLQQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CEMIGRWVVN GEAPNDMNLL GNMVKNICFD NAKAYFK