ID   UXAC_MARMS              Reviewed;         468 AA.
AC   A6VZ14;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Mmwyl1_2780;
OS   Marinomonas sp. (strain MWYL1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Marinomonas.
OX   NCBI_TaxID=400668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MWYL1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y.,
RA   Richardson P.;
RT   "Complete sequence of Marinomonas sp. MWYL1.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000749; ABR71693.1; -; Genomic_DNA.
DR   RefSeq; WP_012070469.1; NC_009654.1.
DR   AlphaFoldDB; A6VZ14; -.
DR   SMR; A6VZ14; -.
DR   STRING; 400668.Mmwyl1_2780; -.
DR   EnsemblBacteria; ABR71693; ABR71693; Mmwyl1_2780.
DR   KEGG; mmw:Mmwyl1_2780; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..468
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000082964"
SQ   SEQUENCE   468 AA;  53159 MW;  B6B37896BD5197C6 CRC64;
     MKNFMTEDFL LTTETAKRLY HEYAADQPIY DYHCHLSPQE IAENRRFTDL GEIWLEGDHY
     KWRAMRTAGI EERLVTGNAS FKEKYQAWAK TVPQCIGNPI YHWTHLELRR PFGITDVLFS
     PKTADAIWDQ CNEMLQQPEF SARGIMQQMK VKMVGTTDDP ADSLEHHKFI ANDNSFDIAV
     TPSWRPDRAF KVDHVGFKDY LNKLGKAADI NITRFSDLIA ALAQRLEVFD AHGCRSADHG
     IEIMRFANEP SETDLDAILT KRINEQALTE LEIAQFSSAV QAWLGKQYAK KGWVMQLHIG
     ARRNNSSRMF KLIGGDSGFD SMDDRAFAEP LSGFLNTLDQ SDELPKTILY CLNPMHNEML
     ATMAGNFQGG GVAGKVQFGS GWWFNDQLDG MQRQLTSVAQ MGLLSQFVGM LTDSRSFLSY
     TRHEYFRRLL CEMIGGWVER GEAPADMALL GEMVKGICAG NAKKYFGF