ID   UXAC_NOSP7              Reviewed;         472 AA.
AC   Q9KHA1; B2J4G2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; Synonyms=hrmI;
GN   OrderedLocusNames=Npun_F5333;
OS   Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=63737;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Campbell E.L., Meeks J.C., Wong F.C.;
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29133 / PCC 73102;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA   Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT   "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AF266466; AAF77061.1; -; Genomic_DNA.
DR   EMBL; CP001037; ACC83652.1; -; Genomic_DNA.
DR   RefSeq; WP_012411603.1; NC_010628.1.
DR   AlphaFoldDB; Q9KHA1; -.
DR   SMR; Q9KHA1; -.
DR   STRING; 63737.Npun_F5333; -.
DR   PRIDE; Q9KHA1; -.
DR   EnsemblBacteria; ACC83652; ACC83652; Npun_F5333.
DR   KEGG; npu:Npun_F5333; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_3; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001191; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172777"
SQ   SEQUENCE   472 AA;  53319 MW;  77770A09BE169BFD CRC64;
     MLTKKPVLSP DRCFSPEPVQ RRLAHQFFDS ISALPLVCPH GHVDPALLAN PAARFGSPTE
     LFIIPDHYIL RMLYSRGVPL EALGIPTRDA PTETDHRKIW QLFAEHFYLF QGTPSGLWLK
     DELTNVFGVD EALNSRNAGR IYDYLEGLLA LPKFSPRALF KRFNIEVLCT TDAASDNLEN
     QRSLHEEGFT QIRPTFRPDA VVNLDAPGWR ENLTKLESSI GREISSYATF VQALEERRAF
     FKKMGATATD QGAATPYTTS LSDQEAEAIF ARALIGKLNP GDVEQFTGHI FMEMARMSVE
     DGLVMQMHCG VMRNHNPALF ERFGSDKGAD IPLNIEWTRN LHPLLSSYGN NQRFRLIIFG
     MDESTYSREM APLAGHYPTI LLGPPWWFHD SVNGMERYFN QVMETAGIYN TAGFNDDTRA
     FVSIPARHNV WRRVACNWLA GLVTRGLVDE EEGYDMARAL AYDLAKSAYK LD