ID   UXAC_OCEIH              Reviewed;         472 AA.
AC   Q8CXN4;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=OB0367;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; BA000028; BAC12323.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8CXN4; -.
DR   SMR; Q8CXN4; -.
DR   STRING; 221109.22776046; -.
DR   EnsemblBacteria; BAC12323; BAC12323; BAC12323.
DR   KEGG; oih:OB0367; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   PhylomeDB; Q8CXN4; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172778"
SQ   SEQUENCE   472 AA;  54549 MW;  C72F673F9D66D47F CRC64;
     MKKFMDDNFL LSNDTAEELF HHYAKDMPII DYHCHLSPKE IYMNKRYSNI TEVWLYGDHY
     KWRAMRAAGV EESLITGDAN DYDKFMAWAE TVPKLIGNPL YNWTHLELQR YFGVDEILNK
     ESGPSIWEKV NKCLAQDDFG VRELINQSNV QVVCTTDDPI DDLSFHQMLV EDDDFSVKVL
     PGFRPDKAIE INQEGFIDYV DSLEKVTSHS TKTYDGFLRA LKSRVDYFHQ NGCSVADHAL
     NTMMFTETTK EKARNYYEKA MNGQKLSPKE ESDFKSFTLV FLGEQYADKG WVMQYHINAL
     RNNNSRMYNN LGPDTGYDAM NDEVISKPLV NLLNELEKKD RLPKTILYSL NPNDNPVIAS
     IIGSFQRGGV PGKLQFGTAW WFNDTKSGMI KQMQTLADIG VFSQFIGMLT DSRSFLSYPR
     HEYFRRLVCS LIGEWVHNGE VPYDLKSLGE IVQDISYYNA ARYFDFGLLS DE