ID   CAGT_HELPY              Reviewed;         280 AA.
AC   P97245;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=CAG pathogenicity island protein 12;
DE   Flags: Precursor;
GN   Name=cagT; Synonyms=cag12; OrderedLocusNames=HP_0532;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 4867 / CCUG 17874 / NCTC 11638;
RX   PubMed=8962108; DOI=10.1073/pnas.93.25.14648;
RA   Censini S., Lange C., Xiang Z., Crabtree J., Ghiara P., Borodovsky M.,
RA   Rappuoli R., Covacci A.;
RT   "cag, a pathogenicity island of Helicobacter pylori, encodes type I-
RT   specific and disease-associated virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:14648-14653(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9593295; DOI=10.1046/j.1365-2958.1998.00770.x;
RA   Akopyants N.S., Clifton S.W., Kersulyte D., Crabtree J.E., Youree B.E.,
RA   Reece C.A., Bukanov N.O., Drazek E.S., Roe B.A., Berg D.E.;
RT   "Analyses of the cag pathogenicity island of Helicobacter pylori.";
RL   Mol. Microbiol. 28:37-53(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- INTERACTION:
CC       P97245; O25258: HP_0522; NbExp=3; IntAct=EBI-2585196, EBI-2506871;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF282852; AAF80203.1; -; Genomic_DNA.
DR   EMBL; AC000108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AE000511; AAD07599.1; -; Genomic_DNA.
DR   PIR; D64586; D64586.
DR   RefSeq; NP_207328.1; NC_000915.1.
DR   RefSeq; WP_000776464.1; NC_000915.1.
DR   PDB; 6OEE; EM; 3.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-280.
DR   PDBsum; 6OEE; -.
DR   AlphaFoldDB; P97245; -.
DR   SMR; P97245; -.
DR   DIP; DIP-3589N; -.
DR   IntAct; P97245; 2.
DR   MINT; P97245; -.
DR   STRING; 85962.C694_02745; -.
DR   TCDB; 3.A.7.12.1; the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.
DR   PaxDb; P97245; -.
DR   EnsemblBacteria; AAD07599; AAD07599; HP_0532.
DR   KEGG; hpy:HP_0532; -.
DR   PATRIC; fig|85962.8.peg.558; -.
DR   OMA; MKMRASV; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0019867; C:outer membrane; IDA:CACAO.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IMP:CACAO.
DR   InterPro; IPR025264; Cag12.
DR   Pfam; PF13117; Cag12; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           21..280
FT                   /note="CAG pathogenicity island protein 12"
FT                   /id="PRO_0000020841"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   VARIANT         3
FT                   /note="L -> V (in strain: NCTC 11638)"
FT   VARIANT         9
FT                   /note="I -> T (in strain: NCTC 11638)"
FT   VARIANT         144
FT                   /note="S -> N (in strain: NCTC 11638)"
SQ   SEQUENCE   280 AA;  32374 MW;  C05AD6F8626C8464 CRC64;
     MKLRASVLIG ATILCLILSA CSNYAKKVVK QKNHVYTPVY NELIEKYSEI PLNDKLKDTP
     FMVQVKLPNY KDYLLDNKQV VLTFKLVHHS KKITLIGDAN KILQYKNYFQ ANGARSDIDF
     YLQPTLNQKG VVMIASNYND NPNSKEKPQT FDVLQGSQPM LGANTKNLHG YDVSGANNKQ
     VINEVAREKA QLEKINQYYK TLLQDKEQEY TTRKNNQREI LETLSNRAGY QMRQNVISSE
     IFKNGNLNMQ AKEEEVREKL QEERENEYLR NQIRSLLSGK