ID   UXAC_OPITP              Reviewed;         472 AA.
AC   B1ZP77;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Oter_4293;
OS   Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1).
OC   Bacteria; Verrucomicrobia; Opitutae; Opitutales; Opitutaceae; Opitutus.
OX   NCBI_TaxID=452637;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11246 / JCM 15787 / PB90-1;
RX   PubMed=21398538; DOI=10.1128/jb.00228-11;
RA   van Passel M.W., Kant R., Palva A., Copeland A., Lucas S., Lapidus A.,
RA   Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J.,
RA   Larimer F.W., Land M.L., Hauser L., Kyrpides N., Mikhailova N.,
RA   Richardson P.P., Janssen P.H., de Vos W.M., Smidt H.;
RT   "Genome sequence of the verrucomicrobium Opitutus terrae PB90-1, an
RT   abundant inhabitant of rice paddy soil ecosystems.";
RL   J. Bacteriol. 193:2367-2368(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001032; ACB77566.1; -; Genomic_DNA.
DR   RefSeq; WP_012377092.1; NC_010571.1.
DR   AlphaFoldDB; B1ZP77; -.
DR   SMR; B1ZP77; -.
DR   STRING; 452637.Oter_4293; -.
DR   EnsemblBacteria; ACB77566; ACB77566; Oter_4293.
DR   KEGG; ote:Oter_4293; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_0; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000007013; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131598"
SQ   SEQUENCE   472 AA;  53732 MW;  8EDE95CD55CE5FCC CRC64;
     MRPFIHDDFL LHTDAARDLY HSFAKAEPIF DYHCHLPQQQ ILENHQFADL AEIWLGGDHY
     KWRAMRANGV KERFCTGAAT PREKFDAWVG AVPHTLRNPL YHWSHLELAR YFGIFDLINQ
     KSADKIWREA NEKLATMRVH DILAANKVAV ICTTDDPADS LEQHEKIKKL GIKTRVYPTF
     RPDKALNVGS PAAYNAWLEK LAGAAKTKIA SFDDFLSALK KRHDDFHAIG GRLSDHGMEN
     CYAEPCTATE AQAIFDAARA GRAASVADQA KFASFMMLEF GRWDAKKGWT KQLHLGALRN
     NNTRLLATLG PDTGFDSIGD FPQTRALSRY LDTLDSTDEL PRTVLYNLNP ADNYAFATMI
     GNFQDGSVPG KMQFGSGWWF LDQKEAMEWQ MNALSNQGLL SRFVGMLTDS RSFLSYTRHE
     YFRRTLCNLI GAEMERGEIP NDRELVGPMV RRICFANARE YFRLELDPSF RG