ID   UXAC_PHEZH              Reviewed;         480 AA.
AC   B4RGF5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=PHZ_c2452;
OS   Phenylobacterium zucineum (strain HLK1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Phenylobacterium.
OX   NCBI_TaxID=450851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HLK1;
RX   PubMed=18700039; DOI=10.1186/1471-2164-9-386;
RA   Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.;
RT   "Complete genome of Phenylobacterium zucineum - a novel facultative
RT   intracellular bacterium isolated from human erythroleukemia cell line
RT   K562.";
RL   BMC Genomics 9:386-386(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000747; ACG78861.1; -; Genomic_DNA.
DR   RefSeq; WP_012522999.1; NC_011144.1.
DR   AlphaFoldDB; B4RGF5; -.
DR   SMR; B4RGF5; -.
DR   STRING; 450851.PHZ_c2452; -.
DR   EnsemblBacteria; ACG78861; ACG78861; PHZ_c2452.
DR   KEGG; pzu:PHZ_c2452; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_5; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001868; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..480
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131599"
SQ   SEQUENCE   480 AA;  53883 MW;  9DD7A35D0A5DD028 CRC64;
     MTRPLRLHPD RLFPADAGTR DIARRLYGSV KDLPIISPHG HTDPEWFAGD APFPDATNLF
     LAPDHYLYRM LYSQGVPLDR LGVPSKAGPS PADPREAWRM LASNMHLFRG TPSSMWLNHV
     FGEVFGFEIE LSAETADLYF DRIGEALQSP AFRPRALFER FNIELLATTE SPTDDLRHHK
     AMRASGWKGR VVTAYRPDPV IDAEHEDFRA SLSRFGELTG QDVESWSGYL QAHRMRRAAF
     MEMGATSTDH GHPTAATADL SLADAEALFR KLLSADFSPA DAELFRAQML TEMARMSLDD
     GLVMQIHPGS FRNHNAGLFA RYGRDKGADI PTRTDYVRAL KPLLDRFGNE RGLSVIVFTL
     DESSYARELA PLAGHYPVLK LGPAWWFHDS PEGMRRFREQ TTETAGFYNT VGFNDDTRAF
     LSIPARHDVA RRIDAGFLAR LVAEHRLSED DAHETAVDLA YNLPKRAYKL DEPARTPAAA