ID   UXAC_PHOLL              Reviewed;         474 AA.
AC   Q7N9X5;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=plu0176;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; BX571859; CAE12471.1; -; Genomic_DNA.
DR   RefSeq; WP_011144578.1; NC_005126.1.
DR   AlphaFoldDB; Q7N9X5; -.
DR   SMR; Q7N9X5; -.
DR   STRING; 243265.plu0176; -.
DR   EnsemblBacteria; CAE12471; CAE12471; plu0176.
DR   GeneID; 24168473; -.
DR   KEGG; plu:plu0176; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   OrthoDB; 167900at2; -.
DR   BioCyc; PLUM243265:PLU_RS00855-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..474
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172779"
SQ   SEQUENCE   474 AA;  54194 MW;  51AC89360D6F34C0 CRC64;
     MKNFMCDDFL LNNETARQLY HEHAADMPIY DYHCHLNPRE IAENRRFDNL GQIWLEGDHY
     KWRAMRCAGI DESLITGKQT RDYEKYQAWA ETVPLTLGNP LYHWTHLELR RPFGISGILF
     GPQTADEIWH QCNEKLAAPA FSARGIMQQM NVRMVGTTDD PVDSLQYHRQ IATDESFDIE
     VLPSWRPDRV FKIELAGFID YIKQLEAVAD VSIVAFADVL NALERRLEHF AAHGCRAADH
     GIENLRYAPI PDETVLNGIL QKRLAGGILS ELEIAQYTTA ILVWLGRQYA ARGWVMQMHI
     GAIRNNNSRM FRLLGADSGF DSIGDNNIAW PLSRLLDSMD VTDELPKTIL YCLNPRDNEV
     IATMASNFQG GGIAGKVQFG SGWWFNDQKD GMLRQLEQLS QLGLLSQFVG MLTDSRSFLS
     YTRHEYFRRI LCNVLGQWAE KGEIPNHKAM LGQIVEDICF NNARRYFALP GENL