ID   UXAC_PHOV8              Reviewed;         468 AA.
AC   A6L4U4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=BVU_3074;
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC   11154;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000139; ABR40708.1; -; Genomic_DNA.
DR   RefSeq; WP_005846562.1; NC_009614.1.
DR   AlphaFoldDB; A6L4U4; -.
DR   SMR; A6L4U4; -.
DR   STRING; 435590.BVU_3074; -.
DR   EnsemblBacteria; ABR40708; ABR40708; BVU_3074.
DR   GeneID; 66750058; -.
DR   KEGG; bvu:BVU_3074; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_10; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   BioCyc; BVUL435590:G1G59-3198-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..468
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044762"
SQ   SEQUENCE   468 AA;  54307 MW;  C9A6BC7A977BAADB CRC64;
     MKNFMDENFL LQTETAQKLY HEHAAKMPII DYHCHLIPQM VADDYQFKSL TEIWLGGDHY
     KWRAMRTNGV DERYCTGKDT TDWEKFEKWA ETVPYTFRNP LYHWTHLELK TAFGINKVLN
     PKTAREIFDE CNEKLAKPEY SARGMMRRYH VETVCTTDDP VDSLEYHIKT RESGFEIKML
     PTWRPDKAMA VEVPADFRAY MEKLSAVSGV TISSFDDMVA ALRKRHDFFA EQGCKLSDHG
     IEEFYAEDYT DAEINAIFNK VYGGTELTKE EILKFKSAML IVFGEMDWEK GWTQQFHYGA
     IRNNNTKMFK LLGPDTGFDS IGEFTTAKAM AKFLDRLNTE GKLTKTILYN LNPCANEVIA
     TMLGNFQDGT IPGKIQFGSG WWFLDQKDGM EKQMNALSLL GLLSRFVGML TDSRSFLSYP
     RHEYFRRTLC NLLGNDVENG EIPACEIERV NQMVEDICYN NAKKFFQF