ID   UXAC_RHILO              Reviewed;         469 AA.
AC   Q98EW1;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=mll4056;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; BA000012; BAB50806.1; -; Genomic_DNA.
DR   RefSeq; WP_010912149.1; NC_002678.2.
DR   AlphaFoldDB; Q98EW1; -.
DR   SMR; Q98EW1; -.
DR   STRING; 266835.14024202; -.
DR   EnsemblBacteria; BAB50806; BAB50806; BAB50806.
DR   KEGG; mlo:mll4056; -.
DR   PATRIC; fig|266835.9.peg.3212; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_5; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..469
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172781"
SQ   SEQUENCE   469 AA;  53525 MW;  5EF8527AA61DC16D CRC64;
     MVALTDPDLL FPPEAHSRSL ARDLYAGIKD LPIVSPHGHT DPRWYALNEP FPDPAQLLIV
     PDHYIFRMLF SQGVRLEDLG VASLDGAPVE TDGRTIWRRF AEHYYLFRGT PTRLWFDHVL
     AHLFGIEEPL DATTADRHYD TIATVLQWEN FRPRALFERF NIEVIATTEG ALDDLEWHKM
     IRDSGWEGRV VTAYRPDAVV DPDFEGFSAN LDRLGEITGC DTGSWAGYLD AHRQRRAFFK
     SFGATSSDHG HPTAETANLS DAAAQELFNR IRRGSQDERE RKLFRAQMLT EMAKMSRDDG
     LVLQIHPGSW RNHSPSVFQR FGRDKGFDIP TRTDYVTALK PLLDCVGLER DLTVILFTLD
     ESSYARELAP LAGVYPALKL GPAWWFHDSP EGMRRFREMT TETAGFYNTV GFNDDTRAFP
     SIPARHDVAR RVDCAFLARL VAEHRLREDE AHELARELAH TLAKKAYRL