ID   UXAC_RHIWR              Reviewed;         466 AA.
AC   A5V7I1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Swit_1887;
OS   Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC
OS   105917 / EY 4224 / RW1) (Sphingomonas wittichii).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Rhizorhabdus.
OX   NCBI_TaxID=392499;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Sphingomonas wittichii RW1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000699; ABQ68247.1; -; Genomic_DNA.
DR   RefSeq; WP_011952725.1; NC_009511.1.
DR   AlphaFoldDB; A5V7I1; -.
DR   SMR; A5V7I1; -.
DR   STRING; 392499.Swit_1887; -.
DR   EnsemblBacteria; ABQ68247; ABQ68247; Swit_1887.
DR   KEGG; swi:Swit_1887; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_5; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001989; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044778"
SQ   SEQUENCE   466 AA;  51847 MW;  09D5ED24D562C79C CRC64;
     MTAAPLRLHP DRLFPADPDT RVVARRLYAE VAGLPIVSPH GHTDPRWFAE DAPFGDASSL
     LLQPDHYVFR MLYSQGVPLE AIGIGAPVDP RAAWRVLADH YHLFRGTPSR LWLDWVFHSV
     FGLDVRLAPE TADLTFDSIN EQLARPEFRP RALFDRFNIE LLATTESPLD PLDHHAAIRA
     SGWTGRVITA FRPDPVVDPD FEGFAANLDR LGAMTGEDVG SYAGYLAALR ARRAAFAAAG
     ATSTDHGHPT AATADLDRGE AERLYAQVRG GGATAEQAEL FRAHMLTVMA EMSIDDGLVM
     QIHPGSFRNH NADLFRRFGR DKGADIPTRT DFVRALRPLL GRFGNDPRLS LILFTLDESA
     YARELAPLAG HYPALKLGPA WWFHDSPEGM RRFRRQTTET AGFHNLVGFN DDTRAFLSIP
     ARHDVARRID CGYLAELVVE HQLDEDEAAD LAVDLTYRLV KSAYRL