ID   UXAC_SALHS              Reviewed;         470 AA.
AC   B4THM8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=SeHA_C3383;
OS   Salmonella heidelberg (strain SL476).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=454169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL476;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001120; ACF67389.1; -; Genomic_DNA.
DR   RefSeq; WP_000190177.1; NC_011083.1.
DR   AlphaFoldDB; B4THM8; -.
DR   SMR; B4THM8; -.
DR   KEGG; seh:SeHA_C3383; -.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001866; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..470
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131604"
SQ   SEQUENCE   470 AA;  53468 MW;  134D5EB2095AA642 CRC64;
     MATFMTEDFL LKNDIARTLY HKYAAPMPIY DFHCHLSPQE IADDRRFDNL GQIWLEGDHY
     KWRALRSAGV DESLITGKET SDYEKYMAWA NTVPKTLGNP LYHWTHLELR RPFGITGTLF
     GPDTAESIWT QCNEKLATPA FSARGIMQQM NVRMVGTTDD PIDSLEYHRQ IAADDSIDIE
     VAPSWRPDKV FKIELDGFVD YLGKLEAAAD VSITRFDDLR QALTRRLDHF AACGCLASDH
     GIETLRFAPV PDDAQLDAIL GKRLAGETLS ELEIAQFTTA VLVWLGRQYA ARGWVMQLHI
     GAIRNNNTRM FRLLGPDTGF DSIGDNNISW ALSRLLDSMD VTNELPKTIL YCLNPRDNEV
     LATMIGNFQG PGIAGKVQFG SGWWFNDQKD GMLRQLEQLS QMGLLSQFVG MLTDSRSFLS
     YTRHEYFRRI LCNLLGQWAQ DGEIPDDEAM LSRMVQDICF NNAQRYFTIK