CAH10_HUMAN
ID CAH10_HUMAN Reviewed; 328 AA.
AC Q9NS85; B2R7J0; B4DGL6;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Carbonic anhydrase-related protein 10;
DE AltName: Full=Carbonic anhydrase-related protein X;
DE Short=CA-RP X;
DE Short=CARP X;
DE AltName: Full=Cerebral protein 15;
GN Name=CA10; ORFNames=hucep-15, UNQ533/PRO1076;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=11311946; DOI=10.1016/s0167-4781(01)00193-2;
RA Okamoto N., Fujikawa-Adachi K., Nishimori I., Taniuchi K., Onishi S.;
RT "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA
RT expressions of CA-RP X and XI in human brain.";
RL Biochim. Biophys. Acta 1518:311-316(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Frontal cortex;
RA Hewett-Emmett D., Shimmin L.C., Wiebauer K., Tashian R.E., Porter C.A.;
RT "Structure and expression of the human CA10 gene: evolution of the highly
RT conserved alpha-carbonic anhydrase-related proteins, CA-RP X and CA-RP
RT XI.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Yoshimoto M., Yazaki M., Takayama K., Matsumoto K., Tsuritani K.;
RT "Molecular cloning of a gene expressed in human cerebral cortex.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9921901; DOI=10.1007/s004390050889;
RA Kleiderlein J.J., Nisson P.E., Jessee J., Li W.B., Becker K.G., Derby M.L.,
RA Ross C.A., Margolis R.L.;
RT "CCG repeats in cDNAs from human brain.";
RL Hum. Genet. 103:666-673(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Does not have a catalytic activity.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NS85-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NS85-2; Sequence=VSP_056940;
CC -!- TISSUE SPECIFICITY: Strong expression in brain and central nervous
CC system. {ECO:0000269|PubMed:11311946}.
CC -!- DEVELOPMENTAL STAGE: Not expressed in fetal brain.
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB036836; BAB00615.1; -; mRNA.
DR EMBL; AF288385; AAK11974.1; -; mRNA.
DR EMBL; AB001597; BAB46928.1; -; mRNA.
DR EMBL; AF064854; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL161812; CAB82105.1; -; mRNA.
DR EMBL; AY358509; AAQ88873.1; -; mRNA.
DR EMBL; AK294652; BAG57827.1; -; mRNA.
DR EMBL; AK313001; BAG35837.1; -; mRNA.
DR EMBL; AC002090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94558.1; -; Genomic_DNA.
DR EMBL; BC020577; AAH20577.1; -; mRNA.
DR EMBL; BC047456; AAH47456.1; -; mRNA.
DR EMBL; BC068462; AAH68462.1; -; mRNA.
DR CCDS; CCDS32684.1; -. [Q9NS85-1]
DR RefSeq; NP_001076002.1; NM_001082533.1. [Q9NS85-1]
DR RefSeq; NP_001076003.1; NM_001082534.1. [Q9NS85-1]
DR RefSeq; NP_064563.1; NM_020178.4. [Q9NS85-1]
DR AlphaFoldDB; Q9NS85; -.
DR SMR; Q9NS85; -.
DR BioGRID; 121259; 49.
DR IntAct; Q9NS85; 27.
DR MINT; Q9NS85; -.
DR STRING; 9606.ENSP00000405388; -.
DR DrugBank; DB00909; Zonisamide.
DR iPTMnet; Q9NS85; -.
DR PhosphoSitePlus; Q9NS85; -.
DR BioMuta; CA10; -.
DR DMDM; 18203320; -.
DR MassIVE; Q9NS85; -.
DR PaxDb; Q9NS85; -.
DR PeptideAtlas; Q9NS85; -.
DR PRIDE; Q9NS85; -.
DR ProteomicsDB; 4142; -.
DR ProteomicsDB; 82509; -. [Q9NS85-1]
DR Antibodypedia; 30804; 205 antibodies from 27 providers.
DR DNASU; 56934; -.
DR Ensembl; ENST00000285273.8; ENSP00000285273.4; ENSG00000154975.14. [Q9NS85-1]
DR Ensembl; ENST00000442502.6; ENSP00000390666.2; ENSG00000154975.14. [Q9NS85-1]
DR Ensembl; ENST00000451037.7; ENSP00000405388.2; ENSG00000154975.14. [Q9NS85-1]
DR Ensembl; ENST00000570565.5; ENSP00000459619.1; ENSG00000154975.14. [Q9NS85-2]
DR GeneID; 56934; -.
DR KEGG; hsa:56934; -.
DR MANE-Select; ENST00000451037.7; ENSP00000405388.2; NM_020178.5; NP_064563.1.
DR UCSC; uc002itw.5; human. [Q9NS85-1]
DR CTD; 56934; -.
DR DisGeNET; 56934; -.
DR GeneCards; CA10; -.
DR HGNC; HGNC:1369; CA10.
DR HPA; ENSG00000154975; Tissue enhanced (brain, cervix, retina).
DR MIM; 604642; gene.
DR neXtProt; NX_Q9NS85; -.
DR OpenTargets; ENSG00000154975; -.
DR PharmGKB; PA25985; -.
DR VEuPathDB; HostDB:ENSG00000154975; -.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000155223; -.
DR HOGENOM; CLU_039326_7_1_1; -.
DR InParanoid; Q9NS85; -.
DR OMA; HKNQNAC; -.
DR OrthoDB; 1377476at2759; -.
DR PhylomeDB; Q9NS85; -.
DR TreeFam; TF352926; -.
DR PathwayCommons; Q9NS85; -.
DR SignaLink; Q9NS85; -.
DR BioGRID-ORCS; 56934; 10 hits in 1069 CRISPR screens.
DR ChiTaRS; CA10; human.
DR GeneWiki; CA10; -.
DR GenomeRNAi; 56934; -.
DR Pharos; Q9NS85; Tbio.
DR PRO; PR:Q9NS85; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9NS85; protein.
DR Bgee; ENSG00000154975; Expressed in cerebellar cortex and 122 other tissues.
DR ExpressionAtlas; Q9NS85; baseline and differential.
DR Genevisible; Q9NS85; HS.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007420; P:brain development; NAS:UniProtKB.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR CDD; cd03121; alpha_CARP_X_XI_like; 1.
DR Gene3D; 3.10.200.10; -; 1.
DR InterPro; IPR041878; Alpha_CARP_X/XI.
DR InterPro; IPR018423; CA10.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR PANTHER; PTHR18952; PTHR18952; 1.
DR PANTHER; PTHR18952:SF91; PTHR18952:SF91; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; SSF51069; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..328
FT /note="Carbonic anhydrase-related protein 10"
FT /id="PRO_0000077436"
FT DOMAIN 31..301
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01134"
FT VAR_SEQ 1..75
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056940"
SQ SEQUENCE 328 AA; 37563 MW; B20BFEC1800422B4 CRC64;
MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW GLVNSAWNLC
SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN TGRHVSLRLD KEHLVNISGG
PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ AFSGEVQLIH YNHELYTNVT EAAKSPNGLV
VVSIFIKVSD SSNPFLNRML NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT
IPPCYETASW IIMNKPVYIT RMQMHSLRLL SQNQPSQIFL SMSDNFRPVQ PLNNRCIRTN
INFSLQGKDC PNNRAQKLQY RVNEWLLK
