ID   UXAC_SERP5              Reviewed;         470 AA.
AC   A8GJX5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Spro_4321;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000826; ABV43415.1; -; Genomic_DNA.
DR   RefSeq; WP_012147018.1; NC_009832.1.
DR   AlphaFoldDB; A8GJX5; -.
DR   SMR; A8GJX5; -.
DR   STRING; 399741.Spro_4321; -.
DR   PRIDE; A8GJX5; -.
DR   EnsemblBacteria; ABV43415; ABV43415; Spro_4321.
DR   KEGG; spe:Spro_4321; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..470
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000061952"
SQ   SEQUENCE   470 AA;  53062 MW;  F77E7E51C7D9B43C CRC64;
     MATFLSEDFL LGNEFARRLY HDYAADQPIF DYHCHLPPEQ IAENTRFKNL YEIWLKGDHY
     KWRAMRTNGV AERLCTGDAG DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGTLLS
     PTTADDIWQR GNALLAQDDF RARGIMQQMN VKMVGTTDDP IDDLRHHKAI AADSSFDIKV
     LPSWRPDKAF NIDAPGFNDY LQKLEAAADI NIGRFSALCD ALKKRMDHFA AHGCKVADHA
     LDVVVYGEAD ESTLDAILTA RLSGKLPTPE QSAQFKSAVL LFLAAEYQRR EWVQQYHIGA
     LRNNNSRMLA SVGPDIGFDS INDRPLAEAL SRLLDAQARQ GGLPKTILYC LNPRDNEVIG
     TMVGNFQGEG TPGKMQFGSG WWFNDQKDGM QRQMTQLAQL GLLSRFVGML TDSRSFLSYT
     RHEYFRRILC QMIGGWVENG EAPADITLLG EMVKNICFDN AKNYFAIELA